Ovine pulmonary adenocarcinoma in slaughtered sheep: A pathological and polymerase chain reaction study
Journal of the South African Veterinary Association
| Field | Value | |
| Title | Ovine pulmonary adenocarcinoma in slaughtered sheep: A pathological and polymerase chain reaction study | |
| Creator | Azizi, Shahrzad Tajbakhsh, Elahe Fathi, Farzad | |
| Description | Ovine pulmonary adenocarcinoma (OPA) is a contagious tumour in sheep caused by jaagsiekte sheep retrovirus (JSRV). This tumour originates from the pneumocyte type II and Clara cells and grossly appears as hard, prominent nodules in different lobes. The clinical signs of the disease are similar to those of other chronic respiratory diseases and are not pathogonomic. Therefore, post mortem examinations and histopathological studies are the most reliable ways to diagnose OPA, particularly subclinical cases of this neoplasm. In this study, out of 1000 sheep lungs grossly inspected, 50 animals were suspected of OPA. The suspected lungs as well as 25 apparently normal lungs were examined by histopathological and PCR methods. The proviral DNA was detected in 1/25 apparently normal lungs and 8/50 of the suspected lungs and subsequently confirmed by histopathological studies. The PCR-positive lung samples from five sheep revealed lesions of ’atypical’ OPA and those from three sheep showed the ’classic’ form of the disease. The tumours were multifocal and the masses were distributed throughout the cranioventral and diaphragmatic lung lobes. The stroma of the tumours in the atypical cases was more severely affected with inflammatory cell infiltration and connective tissue proliferation. The histopathological characteristics of maedi including hyperplasia of the perivascular and peribronchiolar lymphoid cells, interstitial lymphoplasmacytic infiltration and smooth muscle hyperplasia were also associated with OPA, especially the atypical form of this adenocarcinoma. Atypical OPA was more prevalent than the classic form. Geographic and climatic conditions, duration of exposure to the virus and the immune status of individual animals might be responsible for the differences between the two pathological entities of OPA. | |
| Publisher | AOSIS | |
| Date | 2014-02-27 | |
| Identifier | 10.4102/jsava.v85i1.932 | |
| Source | Journal of the South African Veterinary Association; Vol 85, No 1 (2014); 5 pages 2224-9435 1019-9128 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jsava.co.za/index.php/jsava/article/view/932/1350
https://jsava.co.za/index.php/jsava/article/view/932/1351
https://jsava.co.za/index.php/jsava/article/view/932/1352
https://jsava.co.za/index.php/jsava/article/view/932/1349
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