Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus | |
| Creator | Fouche, Gerda Sakong, Bellonah M. Adenubi, Olubukola T. Pauw, Elizabeth Leboho, Tlabo Wellington, Kevin W. Eloff, Jacobus N. | |
| Description | The nematode, Haemonchus contortus, is responsible for major economic losses in the livestock industry. The management of parasites such as H. contortus has been through the use of synthetic parasiticides. This has resulted in the presence of residues in meat and milk, which affects food safety. The development of resistance to available anthelmintics coupled with their high cost has further complicated matters. This has led to the investigation of alternative methods to manage nematodes, including the use of plants and plant extracts as a potential source of novel anthelmintics. Acetone extracts were prepared from 15 South African plant species and their anthelmintic activity determined using the egg hatch assay (EHA). The leaf extract of Cleome gynandra had the best inhibitory activity (68% ± 3%) at a concentration of 2.5 mg/mL, followed by the stem extract of Maerua angolensis (65% ± 5%). The extracts had a relatively low toxicity on Vero cells determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) cellular assay. | |
| Publisher | AOSIS | |
| Date | 2016-07-29 | |
| Identifier | 10.4102/ojvr.v83i1.1164 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 83, No 1 (2016); 7 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/1164/1516
https://ojvr.org/index.php/ojvr/article/view/1164/1517
https://ojvr.org/index.php/ojvr/article/view/1164/1518
https://ojvr.org/index.php/ojvr/article/view/1164/1500
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