Clinical, humoral and IFN g responses of cattle to infection with Mycoplasma mycoides var. mycoides small colony and attempts to condition the pathogenesis of the infection
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Clinical, humoral and IFN g responses of cattle to infection with Mycoplasma mycoides var. mycoides small colony and attempts to condition the pathogenesis of the infection | |
| Creator | Scacchia, M. Sacchini, F. Filipponi, G. Luciani, M. Lelli, R. Tjipura-Zaire, G. Di Provvido, A. Shiningwane, A. Ndiipanda, F. Pini, A. Caporale, V. Hubschle, O.J.B. | |
| Description | Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides var. mycoides small colony (MmmSC), is one of the most important diseases of cattle in Africa. The role of innate or acquired cell mediated and humoral immunity in conferring protection against MmmSC infection has not yet been elucidated. On the other hand, the pathological lesions caused by the aetiological agent have been considered indicative of an immunopathological process. In this study ten nave cattle were exposed to in-contact infection with animals infected by intubation with a strain of MmmSC. Clinical signs, antibody response, IFNg release and pathological changes at necropsy were analysed and compared with the events following in-contact infection of an equal number of animals kept under daily treatment with cyclosporine for the entire observation period of 84 days. Cyclosporine is a suppressor of the immune response related to the T-cell system. Under the conditions of the experiment, cyclosporine appeared to condition the pathogenesis of CBPP by delaying the events that follow infection, bringing further support to the possibility that the immune response may have an impact on the disease outcome. | |
| Publisher | AOSIS | |
| Date | 2007-09-13 | |
| Identifier | 10.4102/ojvr.v74i3.128 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 74, No 3 (2007); 251-263 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/128/123
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