Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005)
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Evolution of antimicrobial resistance of Salmonella enteritidis (1972–2005) | |
| Creator | Khumalo, Jermaine Saidi, Bamusi Mbanga, Joshua | |
| Description | With the extensive use of antibiotics in livestock production, surveillance revealed an increase in Salmonella resistance to the commonly used antimicrobials in veterinary and public health. This serious threat to health care is further exacerbated by the limited epidemiological information about the common zoonotic agent, Salmonella enteritidis, required to determine antibiotic therapy. The aim was to characterise the antimicrobial resistance patterns of S. enteritidis isolates across different timelines (1972–2005) with accompanying genetic changes being investigated. Thirty-seven stored S. enteritidis isolates were collected from the Central Veterinary Laboratory, Harare, with antimicrobial susceptibility determined against eight antibiotics. Plasmids were isolated to analyse any genetic variation. An overall significant increase in resistance (p 0.05) to nalidixic acid (0% – 10%), ampicillin (14.3% – 50%), tetracycline (14.3% – 30%) and erythromycin (71.4% – 100%) was observed across the timeline. However, the highest rates of susceptibility were maintained for gentamicin, sulphamethoxazole-trimethoprim, kanamycin and chloramphenicol. We report an increase in multidrug resistance (MDR) of 14.2% – 50% with an increase in resistotypes and plasmid profiles across the timeline. Eleven plasmid profiles were obtained in the 37 isolates studied with a minority of isolates (21.6%, 8/37) harbouring a 54 kb plasmid, commonly serovar-specific. A concerning increase in antimicrobial resistance to commonly administered drugs was observed across the timeline. The surge in MDR is of great concern and implies the need for consistent antimicrobial stewardship. No correlation was observed between the plasmid and antibiotic profiles. | |
| Publisher | AOSIS | |
| Date | 2014-11-12 | |
| Identifier | 10.4102/ojvr.v81i1.807 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 81, No 1 (2014); 6 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/807/1185
https://ojvr.org/index.php/ojvr/article/view/807/1186
https://ojvr.org/index.php/ojvr/article/view/807/1187
https://ojvr.org/index.php/ojvr/article/view/807/1147
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