Scanning electron microscopy investigation of fibrin networks after thermal injury
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Scanning electron microscopy investigation of fibrin networks after thermal injury | |
| Creator | Pretorius, Etheresia Olivier, Jeané Oberholzer, Hester M. van der Spuy, Wendy J. | |
| Description | Injury due to burning is known to impact on coagulation and haemostasis by disturbing the coagulation cascade and is also associated with impaired fibrinolysis. Also, venous thrombosis, pulmonary embolism and hypercoagulability are common during thermal injury. Using a Wistar albino rat model, we investigated in this study whether burn injury affects the ultrastructure of the fibrin networks. A typical fibrin network will contain mostly major, thick fibres with minor, thin fibres distributed amongst them. We found that the clot architecture changes after burn injury, showing more prominent minor, thin fibres in a netted appearance. Also, the clot showed areas of matted fibrin. We suggest that the thrombotic events associated with burn injury are due to the thickened and netlike areas formed when thrombin activates the coagulation cascade. This is due to impaired fibrinolysis activities, causing the resulting fibrin clots not to be successfully disseminated. Small fragments of these netted, clumped areas may therefore break loose and lead to thrombotic events after burn injuries. The current study therefore provided morphological evidence for thrombotic events associated with burn injury. | |
| Publisher | AOSIS | |
| Date | 2011-07-04 | |
| Identifier | 10.4102/ojvr.v78i1.244 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 78, No 1 (2011); 4 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/244/324
https://ojvr.org/index.php/ojvr/article/view/244/336
https://ojvr.org/index.php/ojvr/article/view/244/326
https://ojvr.org/index.php/ojvr/article/view/244/312
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/244/161
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/244/162
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