Immunohaematological reference values for HIV-negative healthy adults in Botswana
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Immunohaematological reference values for HIV-negative healthy adults in Botswana | |
| Creator | Mine, Madisa Moyo, Sikhulile Stevens, Penny Michael, Kurt Novitsky, Vladimir Makhaola, Kgomotso Asmelash, Aida Molefhabangwe, S’khatele Woldegabriel, Elias Mothowaeng, Gaseboloke Maruta, Talkmore Kamhukamwe, Charity Mangwendeza, Phibeon M. Holmes-Pretorius, Molly Mtoni, Isaac Motswaledi, Modisa Musonda, Rosemary Ndwapi, Ndwapi Makhema, Joseph Marlink, Richard Seipone, Khumo Gaolathe, Tendani Essex, Max | |
| Description | Background: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers’ kits and textbooks. Objectives: The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana.Method: A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured.Results: The mean age was 28.8 (95% Confidence Interval [CI] 27.7–29.8) years, with a median of 27 years and a range 18–66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% – 12.7%) than men (15.1 g/dL; 95% CI 14.9% – 15.3%). The women’s haemoglobin reference values (9.0 g/dL – 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL – 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL – 15.8 g/dL) recently defined for East and Southern Africa.Conclusion: The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally. | |
| Publisher | AOSIS | |
| Date | 2011-12-15 | |
| Identifier | 10.4102/ajlm.v1i1.5 | |
| Source | African Journal of Laboratory Medicine; Vol 1, No 1 (2012); 7 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
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