Diagnosis of rifampicin-resistant tuberculosis: Discordant results by diagnostic methods
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Diagnosis of rifampicin-resistant tuberculosis: Discordant results by diagnostic methods | |
| Creator | Mwanza, Winnie Milimo, Deborah Chilufya, Maureen M. Kasese, Nkatya Lengwe, Maina C. Munkondya, Stembiso de Haas, Petra Ayles, Helen Muyoyeta, Monde | |
| Description | The performance of the Xpert© MTB/RIF and MTBDRplus assays for the detection of rifampicin resistant Mycobacterium tuberculosis was compared to culture-based drug susceptibility testing in 30 specimens with rifampicin-resistant and rifampicin-indeterminate Xpert MTB/RIF results collected between March 2012 and March 2014. Xpert MTB/RIF and MTBDRplus were 100% sensitive and 100% concordant for rifampicin resistance detection, but 3 of 13 samples (23%) positive for rifampicin resistance on Xpert MTB/RIF and MTBDRplus were negative for rifampicin resistance on mycobacteria growth indicator tube drug susceptibility testing. Specificity was 72% for Xpert MTB/RIF and 80% for MTBDRplus. Positive predictive value for Xpert MTB/RIF for multidrug resistant tuberculosis was 47.8% for new patients and 77.8% for previously treated patients; negative predictive value was 100% for both new and previously treated patients. The discordant rifampicin resistance test results indicate a need to fully characterise circulating rifampicin resistant Mycobacterium tuberculosis strains in Zambia and to inform the development of guidelines for decision-making in relation to diagnosis of drug-resistant tuberculosis. | |
| Publisher | AOSIS | |
| Date | 2018-12-06 | |
| Identifier | 10.4102/ajlm.v7i2.806 | |
| Source | African Journal of Laboratory Medicine; Vol 7, No 2 (2018); 4 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/806/1229
https://ajlmonline.org/index.php/ajlm/article/view/806/1228
https://ajlmonline.org/index.php/ajlm/article/view/806/1230
https://ajlmonline.org/index.php/ajlm/article/view/806/1172
|
|
ADVERTISEMENT
