Intravascular plasma disposition and salivary secretion of closantel and rafoxanide in sheep
Journal of the South African Veterinary Association
| Field | Value | |
| Title | Intravascular plasma disposition and salivary secretion of closantel and rafoxanide in sheep | |
| Creator | Swan, G.E. Koeleman, H.A. Steyn, H.S. Mülders, M.S.G. | |
| Description | The plasma and salivary disposition of closantel and rafoxanide were examined following intravenous administration in adult sheep. Two studies were conducted with rafoxanide at 7.5 mg/kg and 1 with closantel using 2 doses (5 and 15 mg/kg). The pharmacokinetic profile of both drugs in plasma were best described by a 2-compartmental model with 1st-order rate constants. Plasma disposition of closantel and rafoxanide were characterised by a rapid distribution (t1/2(a) of 30 min), long elimination half-life (t1/2(b) of 17.0 + 4.0 days for closantel and 7.2 + 0.6 days for rafoxanide), small apparent volume of distribution (Vss of 0.15 ℓ/kg) and a slow rate of total body clearance (Cl of 0.01mℓ/min/kg). The area under the drug plasma concentration curve (AUC) of closantel at 5 mg/kg was nearly twice as large as that of rafoxanide at 7.5 mg/kg resulting from the slower t1/2(b) observed with closantel compared to rafoxanide. Large individual differences were observed in the rate measurements of distribution (k12, k21 and t1/2(a)), whereas the parameters of elimination (k10, t1/2(b) and Cl), were more consistent between animals. A dose proportional increase in AUC was observed for closantel administered at 5 and 15 mg/kg. A low, constant salivary concentration of closantel (mean of 0.04+0.05 mg/mℓ) and rafoxanide (mean of 0.07+0.04 mg/mℓ) was observed during the 24-h examination period after dosing. | |
| Publisher | AOSIS | |
| Date | 1999-07-12 | |
| Identifier | 10.4102/jsava.v70i2.758 | |
| Source | Journal of the South African Veterinary Association; Vol 70, No 2 (1999); 75-79 2224-9435 1019-9128 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jsava.co.za/index.php/jsava/article/view/758/730
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