Comparing adults with severe SARS-CoV-2 or influenza infection: South Africa, 2016–2021
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Comparing adults with severe SARS-CoV-2 or influenza infection: South Africa, 2016–2021 | |
| Creator | Els, Fiona Kleynhans, Jackie Wolter, Nicole du Plessis, Mignon Moosa, Fahima Tempia, Stefano Makhasi, Mvuyo Nel, Jeremy Dawood, Halima Meiring, Susan von Gottberg, Anne Cohen, Cheryl Walaza, Sibongile | |
| Description | Background: Comparisons of the characteristics of individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or seasonal influenza in low-to middle-income countries with high human immunodeficiency virus (HIV) prevalence are limited.Objectives: Determine the epidemiological differences with those hospitalised with influenza or SARS-CoV-2 infection.Method: We investigated hospitalised individuals ≥18 years of age testing positive for seasonal influenza (2016–2019) or SARS-CoV-2 (2020–2021). We used random effects multivariable logistic regression, controlling for clustering by site, to evaluate differences among adults hospitalised with influenza or SARS-CoV-2 infection.Results: Compared to individuals with influenza, individuals with SARS-CoV-2 infection were more likely to be diabetic (adjusted odds ratio [aOR]: 1.70, 95% confidence interval [CI]: 1.11–2.61) or die in hospital (aOR: 2.57, 95% CI: 1.61–4.12). Additionally, those with SARS-CoV-2 infection were less likely to be living with HIV (not immunosuppressed) (aOR: 0.50, 95% CI: 0.34–0.73) or living with HIV (immunosuppressed) (aOR: 0.27, 95% CI: 0.18–0.39) compared to not living with HIV and less likely to be asthmatic (aOR: 0.21, 95% CI: 0.13–0.33) rather than those living with influenza.Conclusion: Individuals hospitalised with SARS-CoV-2 had different characteristics to individuals hospitalised with influenza before the coronavirus disease 2019 (COVID-19) pandemic. Risk factors should be considered in health management especially as we move into an era of co-circulation of SARS-CoV-2 and influenza pathogens.Contribution: Identifying groups at high risk of severe disease could help to better monitor, prevent and control SARS-CoV-2 or influenza severe disease. | |
| Publisher | AOSIS | |
| Date | 2024-07-26 | |
| Identifier | 10.4102/sajid.v39i1.574 | |
| Source | Southern African Journal of Infectious Diseases; Vol 39, No 1 (2024); 10 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
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https://sajid.co.za/index.php/sajid/article/view/574/1548
https://sajid.co.za/index.php/sajid/article/view/574/1549
https://sajid.co.za/index.php/sajid/article/view/574/1550
https://sajid.co.za/index.php/sajid/article/view/574/1551
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