Staphylococcus aureus bacteraemia cases at Helen Joseph Hospital
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Staphylococcus aureus bacteraemia cases at Helen Joseph Hospital | |
| Creator | John, Mithra Richards, Lauren Nel, Jeremy S. | |
| Description | Background: Staphylococcus aureus bacteraemia (SAB) is associated with a high mortality. Data on SAB cases in South Africa (SA) are limited.Objectives: This study aimed to establish the demographic profile, risk factors and complications of patients with SAB in a tertiary inpatient setting.Method: We conducted a retrospective record review of inpatients above the age of 13 with SAB from October 2015 to November 2022 at Helen Jospeh Hospital (HJH) in Gauteng, SA.Results: A total of 126 patients with SAB were reviewed. The case fatality ratio among these patients was 20.6% (95% confidence interval [CI]: 13.9–28.8); this was similar for methicillin-sensitive S. aureus and methicillin-resistant S. aureus (p = 0.154). Almost half (49.2%) were community acquired, and these were chiefly associated with skin and soft tissue infections (45.2%), while most healthcare-associated community-acquired infections (18.3%) and nosocomial-related infections (32.5%) were associated with short-term venous catheterisation (40.6%). The most common risk factors for acquiring a SAB were prior hospitalisation in the last 90 days (27.8%), the presence of an invasive device (26.2%) and receipt of haemodialysis (15.1%). Having hypertension (adjusted odds ratio: 5.55 [95% CI: 1.31–23.55]) and being recently hospitalised (adjusted odds ratio: 11.88 [95% CI: 1.84–26.99]) were associated with statistically significant increased odds of death.Conclusion: SAB-associated all-cause mortality remains high in a middle-income tertiary hospital setting, albeit with a case fatality ratio comparable to that seen in high-income countries.Contribution: Our study suggests that acceptable outcomes are achievable in tertiary middle-income settings provided there is access to resources including infectious diseases consultation, echocardiograms and basic infection control practices. | |
| Publisher | AOSIS Publishing | |
| Date | 2024-05-27 | |
| Identifier | 10.4102/sajid.v39i1.626 | |
| Source | Southern African Journal of Infectious Diseases; Vol 39, No 1 (2024); 7 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/626/1486
https://sajid.co.za/index.php/sajid/article/view/626/1487
https://sajid.co.za/index.php/sajid/article/view/626/1488
https://sajid.co.za/index.php/sajid/article/view/626/1489
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