Gardasil® as adjunctive therapy for respiratory papillomatosis at Red Cross Children’s Hospital, Cape Town
Journal of the Colleges of Medicine of South Africa
| Field | Value | |
| Title | Gardasil® as adjunctive therapy for respiratory papillomatosis at Red Cross Children’s Hospital, Cape Town | |
| Creator | Frank, Shavina McGuire, Jessica K. Kabagenyi, Fiona Pretorius, Vincent Peer, Shazia | |
| Description | Background: Juvenile onset recurrent respiratory papillomatosis (JoRRP) is an incurable condition caused by human papilloma virus (HPV) types 6 and 11, often requiring repeated surgeries and in severe cases, tracheostomy. This imposes a significant socioeconomic burden on patients and families. Gardasil®, a proven prophylactic HPV vaccine, is emerging as a potential adjuvant therapy. We studied its response on JoRRP patients at our center.Methods: We conducted a retrospective review at Red Cross War Memorial Children’s Hospital from January 2015 to June 2022 on histologically confirmed JoRRP cases. Age at diagnosis, baseline and post-dosing Derkay-Coltrera (DC) scores (disease severity measure), inter-surgical intervals and tracheostomy, were collected.Results: Twenty-five of 30 confirmed cases were included. Average age at diagnosis was 60 months (about 5 years old), with HPV Type 6 in 40% and Type 11 in 48% of patients. All patients received at least one Gardasil® dose, 84% received a second dose and 64% a third dose. Total population DC score decreased from an average of 17 (range: 4-34) pre-first dose to 8 (range: 0-16) after three doses, indicating a 50% reduction. Surgical intervals modestly increased. More significant improvements were seen in patients with aggressive forms of the disease.Conclusion: This is the first study in Southern Africa highlighting Gardasil® as adjuvant therapy. Despite our limited sample size, new cases observed a linear reduction in DC scores and tracheostomy rates.Contribution: This suggests that Gardasil® as adjuvant therapy has the potential to reduce disease severity and extend surgical intervals. | |
| Publisher | AOSIS | |
| Date | 2024-05-24 | |
| Identifier | 10.4102/jcmsa.v2i1.33 | |
| Source | Journal of the Colleges of Medicine of South Africa; Vol 2, No 1 (2024); 4 pages 2960-110X | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jcmsa.org.za/index.php/jcmsa/article/view/33/124
https://jcmsa.org.za/index.php/jcmsa/article/view/33/125
https://jcmsa.org.za/index.php/jcmsa/article/view/33/126
https://jcmsa.org.za/index.php/jcmsa/article/view/33/127
|
|
ADVERTISEMENT
