Evaluation of mucin changes between daily and extended wear silicone hydrogel contact lenses

African Vision and Eye Health

Field Value
Title Evaluation of mucin changes between daily and extended wear silicone hydrogel contact lenses
Creator Rhendy, Rio Rahayu, Tri Edwar, Lukman Sadikin, Mohamad Kekalih, Aria
Subject Medicine; opthalmologyst; primary care; ophthalmology; vision science; eye health Lotrafilcon B; MUC5AC; Ferning-type; daily and extended wear lenses; myopia; contact lenses
Description Background: Initially, contact lenses were recommended only for daily wear because of infection and discomfort concerns. With rising demand, particularly for overnight use, extended wear lenses have gained significance. Despite concerns, intensive development of materials like Lotrafilcon B aims to meet this demand, focusing on comfort and safety.Aim: This study aimed to evaluate the mucin quantity and quality changes between daily and extended wear (Lotrafilcon B), impacting eye health and comfort.Setting: The study was conducted at Kirana Eye Center, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Methods: This study was a single-blinded randomised clinical trial with two parallel groups. Forty (40) eligible subjects willingly participated. Mucin 5AC (MUC5AC) and Ferning-type tests were conducted. The 40 subjects with moderate myopia were then divided into a daily wear and an extended wear group. The MUC5AC test was performed at pre-fitting and at 4 weeks, whereas the Ferning-type tests were taken at pre-fitting and 1st and 4th weeks.Results: For both groups, there was a significant increase in MUC5AC levels from pre-fitting to week four, but with no significant difference between them in final MUC5AC levels. Additionally, the comparison of eyes with normal and abnormal Ferning-types between the two groups showed no significant differences at pre-fitting, 1st and 4th weeks.Conclusion: There is no significant difference in MUC5AC levels with the use of daily or extended wear (with Lotrafilcon B).Contribution: This study compares the impact of daily and extended wear Lotrafilcon B contact lenses on eye health and comfort in moderate myopia patients.
Publisher AOSIS
Date 2024-04-16
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — This study used a single-blind randomized clinical trial with a two-parallel group design
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/aveh.v83i1.884
Source African Vision and Eye Health; Vol 83, No 1 (2024); 5 pages 2410-1516 2413-3183
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://avehjournal.org/index.php/aveh/article/view/884/2362 https://avehjournal.org/index.php/aveh/article/view/884/2363 https://avehjournal.org/index.php/aveh/article/view/884/2364 https://avehjournal.org/index.php/aveh/article/view/884/2365
Coverage Indonesia; Jakarta November 2016 – Februari 2017 Age; Astigmatism component
Rights Copyright (c) 2024 Rio Rhendy, Tri Rahayu, Lukman Edwar, Mohamad Sadikin, Aria Kekalih https://creativecommons.org/licenses/by/4.0