Human papillomavirus positivity and cervical lesions in relation to HIV infection: a comparative assessment in the Cameroonian female population

Journal of Public Health in Africa

Field Value
Title Human papillomavirus positivity and cervical lesions in relation to HIV infection: a comparative assessment in the Cameroonian female population
Creator Sosso, Samuel M. Tchouaket, Michel C.T. Fokam, Joseph Simo, Rachel K. Semengue, Ezechiel N.J. Sando, Zacharie Torimiro, Judith Tiga, Aline Lobe, Elise E. Ambada, Georgia Nange, Achille Nka, Alex D. Chenwi, Collins Abba, Aissatou Ka’e, Aude C. Fainguem, Nadine Zam, Marie K.N. Yagai, Bouba Billong, Serge C. Colizzi, Vittorio Ndjolo, Alexis
Subject — CVS; HR-HPV; HIV; Cameroon
Description Cervical lesions, induced by high-risk oncogenic human papillomavirus (HR-HPV), in the context of HIV remains a global health challenge. We determined the effect of HR-HPV on the development of cervical lesions in women with and without HIV infection. A cross-sectional analytical study was conducted among 257 women living in Cameroon. HIV serology, HR-HPV genotyping and cervico-vaginal smear (CVS) were performed for all participants; among those declared HIV positive, plasma HIV viral load and CD4 count were measured. Statistical analyses were performed using Graph Pad version 6.0; P0.05 was considered statistically significant. The mean age of the participants in our study was 37±6.5 years. According to HIV serology, 184 (71.59%) were HIV‑positive vs. 73 (28.40%) HIV‑negative. Among the HIV‑positive women, the median CD4 count was 438 [IQR: 317‑597] cells/mm3 and the median viremia was 40 [IQR:40‑2318] copies/ml. After successful genotyping, the prevalence of HR‑HPV was 36.32% (73/201), with a significantly higher proportion in HIV‑infected individuals (41.98% (55/131) vs. 25.71% (18/70); P=0.02; OR=2.1). The overall rate of cervical lesions was 23.34% (60/257), with a non‑significantly higher proportion in HIV‑infected participants (25.00%(46/184) vs. 19.17% (14/73); P=0.31). Relevantly, the presence of HR‑HPV was significantly associated with cervical lesions (P0.0001; OR=5.07), with a higher odds of cervical lesion in HIV‑positive individuals (P0.0001 and OR=5.67) compared to HIV‑negative individuals (P=0.03 and OR=3.83). Although oncogenic HPV appears to be an independent factor in the development of cervical lesions, this study reveals higher odds of cervical lesions among HIV/HPV co-infection than in HPV infection alone.
Publisher AOSIS
Date 2023-10-30
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format application/pdf
Identifier 10.4081/jphia.2023.2334
Source Journal of Public Health in Africa; Vol 14, No 10 (2023); 7 2038-9930 2038-9922
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
Coverage — — —
Rights Copyright (c) 2024 Samuel M. Sosso, Michel C.T. Tchouaket, Joseph Fokam, Rachel K. Simo, Ezechiel N.J. Semengue, Zacharie Sando, Judith Torimiro, Aline Tiga, Elise E. Lobe, Georgia Ambada, Achille Nange, Alex D. Nka, Collins Chenwi, Aissatou Abba, Aude C. Ka’e, Nadine Fainguem, Marie K.N. Zam, Bouba Yagai, Serge C. Billong, Vittorio Colizzi, Alexis Ndjolo