Exploring NFkB pathway as a potent strategy to mitigate COVID-19 severe morbidity and mortality

Journal of Public Health in Africa

Field Value
Title Exploring NFkB pathway as a potent strategy to mitigate COVID-19 severe morbidity and mortality
Creator Muhammad, Mubarak Hassan, Tasneem M. Baba, Sani S. Radda, Mustapha I. Mutawakkil, Mubarak M. Musa, Majida A. AbuBakar, Sazaly Loong, Shih Keng Yusuf, Ibrahim
Subject — COVID-19; SARS-CoV-2; NFkB; cytokine storm
Description The pandemic of coronavirus disease 2019 (COVID-19), for which there does not appear to be an approved cure, the primary treatment options consist of non-pharmacological preventive measures and supportive treatment that are aimed at halting the progression of the disease. Nuclear factor kappa B (NFkB) presents a promising therapeutic opportunity to mitigate COVID-19-induced cytokine storm and reduce the risk of severe morbidity and mortality resulting from the disease. However, the effective clinical application of NFkB modulators in COVID-19 is hampered by a number of factors that must be taken into consideration. This paper therefore explored the modulation of the NFB pathway as a potential strategy to mitigate the severe morbidity and mortality caused by COVID-19. The paper also discusses the factors that form the barrier, and it offers potential solutions to the various limitations that may impede the clinical use of NFkB modulators against COVID-19. This paper revealed and identified three key potential solutions for the future clinical use of NFkB modulators against COVID-19. These solutions are pulmonary tissue-specific NFkB blockade, agents that target common regulatory proteins of both canonical and non-canonical NFkB pathways, and monitoring clinical indicators of hyperinflammation and cytokine storm in COVID-19 prior to using NFkB modulators.
Publisher AOSIS
Date 2022-09-07
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format application/pdf
Identifier 10.4081/jphia.2022.1679
Source Journal of Public Health in Africa; Vol 13, No 3 (2022); 10 2038-9930 2038-9922
Language eng
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Rights Copyright (c) 2024 Mubarak Muhammad, Tasneem M. Hassan, Sani S. Baba, Mustapha I. Radda, Mubarak M. Mutawakkil, Majida A. Musa, Sazaly AbuBakar, Shih Keng Loong, Ibrahim Yusuf https://creativecommons.org/licenses/by/4.0