Sero-prevalence of anti-SARS-CoV-2 antibodies among communities between July and August 2022 in Bangui, Central African Republic
Journal of Public Health in Africa
| Field | Value | |
| Title | Sero-prevalence of anti-SARS-CoV-2 antibodies among communities between July and August 2022 in Bangui, Central African Republic | |
| Creator | Manirakiza, Alexandre Malaka, Christian Longo, Jean de Dieu Yambiyo, Brice Martial Diemer, Saint-Calver Henri Namseneï, Joella Coti-Reckoundji, Cathy Sandra Gomelle Bouhouda, Modeste Darnycka Belizaire, Marie Roseline Roungou, Jean Baptiste Komas, Narcisse Patrice Grésenguet, Gérard Vernet, Guy Vernet, Marie-Astrid Nakoune, Emmanuel | |
| Description | Background. Large-scale population-based seroprevalence studies of SARS-CoV-2 are essential to characterize the cumulative incidence of SARS-CoV-2 infection and to extrapolate the prevalence of presumptive immunity at the population level.Objective. The objective of our survey was to estimate the cumulative population immunity for COVID-19 and to identify individual characteristics associated with positive serostatus.Materials and Methods. This was a clustered cross-sectional study conducted from July 12 to August 20, 2021, in households in the city of Bangui, the capital of the Central African Republic. Information regarding demographic characteristics (age, gender, and place of residence), and comorbidities (chronic diseases) was collected. A venous blood sample was obtained from each participant to determine the level of total anti-SARS-CoV-2 antibodies using a WANTAI SARS-CoV-2 Ab ELISA kit.Results. All up, 799 participants were surveyed. The average age was 27 years, and 45.8% of the respondents were male (sex ratio: 0.8). The overall proportion of respondents with positive serostatus was 74.1%. Participants over 20 years of age were twice as likely to have positive serostatus, with an OR of 2.2 [95% CI: (1.6, 3.1)].Conclusions. The results of this survey revealed a high cumulative level of immunity in Bangui, thus indicating a significant degree of spread of SARS-CoV-2 in the population. The public health implications of this immunity to SARS-CoV-2 such as the post-vaccination total antibody kinetics remain to be determined. | |
| Publisher | AOSIS | |
| Date | 2023-08-30 | |
| Identifier | 10.4081/jphia.2023.2315 | |
| Source | Journal of Public Health in Africa; Vol 14, No 8 (2023); 4 2038-9930 2038-9922 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://publichealthinafrica.org/index.php/jphia/article/view/89/194
https://publichealthinafrica.org/index.php/jphia/article/view/89/98
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