The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation

Journal of Public Health in Africa

Field Value
Title The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation
Creator Isadiartuti, Dewi Ekowati, Juni Rosita, Noorma Amalia, Nabella R.
Subject — Dissolution, p-methoxycinnamic acid; β-cyclodextrin; Microwave irradiation; Drug
Description ackground: p-methoxycinnamic acid (pMCA) is an ethyl p-methoxycinnamic derivative, which is the largest active ingredient in the rhizome of the kencur (Kaempferia galanga L) plant. Several studies reported that the compound has anti-inflammatory activity but has low solubility in water. The formation of a pMCA-β-cyclodextrin (βCD) inclusion complex with a molar ratio of 1:1 can increase its solubility. The formation of inclusion complexes with conventional methods requires a long time and the yield value is not optimal. Objective: This study aims to evaluate the dissolution of the pMCA-βCD inclusion complex produced using the microwave irradiation method. Methods: The product was manufactured with chloroform solvent and a power of 400 watts (power 80%). It was then evaluated using the Differential Thermal Analysis (DTA) every 2 minutes until the 8th minute. The reaction was complete after 4 minutes of treatment with a yield of 96.5%. The obtained inclusion complexes were evaluated using DTA, FTIR, and PXRD. Subsequently, a dissolution test was carried out using a type 2 apparatus in distilled water medium of pH 6.8±0.05 at 37±0.5°C. Results: The results showed that there was a change in the melting temperature profile, infrared spectra, and crystallinity of the product. An 89.18% dissolution was also obtained within 60 minutes, which was twice that of pMCA compounds. Conclusion: From the results of the study, it can be concluded that the formation of pMCA-βCD inclusion complexes using the microwave irradiation method is capable of providing high-yield values in a short time.
Publisher AOSIS
Date 2023-03-30
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format application/pdf
Identifier 10.4081/jphia.2023.2500
Source Journal of Public Health in Africa; Vol 14, S 1 (2023): 4th Joint Conference of UNAIR-USM, International Conference of Pharmacy and Health Sciences (ICPHS); 7 2038-9930 2038-9922
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
Coverage — — —
Rights Copyright (c) 2024 Dewi Isadiartuti, Juni Ekowati, Noorma Rosita, Nabella R. Amalia