A study of human epidermal growth factor receptor 2 overexpression by immunohistochemistry in patients with gastric adenocarcinoma

Journal of Public Health in Africa

Field Value
Title A study of human epidermal growth factor receptor 2 overexpression by immunohistochemistry in patients with gastric adenocarcinoma
Creator Abood, Rafid A. Alomar, Saad Alharoon, Sawsan S.
Subject — gastric cancer; adenocarcinoma; HER2 overactivity; Iraq; clinicopathological features; prevalence
Description Gastric cancer is one of the leading causes of cancer‑related deaths across the world and in the Middle East. Human epidermal growth factor receptor 2 (HER2) overexpression has been observed in gastric cancers. Trastuzumab, a recombinant monoclonal antibody targeting HER2 protein, is being used for treatment of metastatic gastric cancer. To study the frequency and association of HER2 overexpression with age, gender, histopathological subtype and grade of differentiation in patients with gastric adenocarcinoma from Basra, Iraq. This cross‑sectional single‑center study collected demographic (age, gender), histopathological (histological subtype, grade of differentiation) and immunohistochemical (HER2 overexpression status) data from 100 consenting adult patients (male: 56) with histopathologically confirmed gastric adenocarcinoma from samples obtained through endoscopy or surgery. HER2 overexpression (ToGA score 3+) was observed in 6/100 (6%) of patients, with another 6 showing ‘equivocal’ HER2 expression (2+). Out of 20 patients with moderately differentiated gastric cancer, 4 (20%) showed HER2 overexpression (P=0.008). Other factors considered (age, gender, histological subtype) did not show statistically significant correlation with HER2 overexpression. More females showed HER2 overexpression than males (4 vs. 2), and more patients with intestinal type gastric cancer showed HER2 overexpression than diffuse gastric cancer (5 vs. 1), but the difference was not statistically significant in both variables. HER2 overexpression was 6% in this population; statistically significant correlation was found with histological grade. Statistically non‑significant correlations were observed between HER2 overexpression and gender, age, and histological subtype.
Publisher AOSIS
Date 2023-09-30
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/xml application/pdf
Identifier 10.4081/jphia.2023.2721
Source Journal of Public Health in Africa; Vol 14, No 9 (2023); 4 2038-9930 2038-9922
Language eng
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https://publichealthinafrica.org/index.php/jphia/article/view/138/162 https://publichealthinafrica.org/index.php/jphia/article/view/138/161
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Rights Copyright (c) 2024 Rafid A. Abood, Saad Alomar, Sawsan S. Alharoon https://creativecommons.org/licenses/by/4.0