Loss of function of the meibomian glands among HIV and AIDS individuals undergoing antiretroviral therapy

African Vision and Eye Health

Field Value
Title Loss of function of the meibomian glands among HIV and AIDS individuals undergoing antiretroviral therapy
Creator Mathebula, Solani D. Ntsoane, Mologadi D.
Subject — AIDS; dry eye; HIV; meibomian gland; meibomian gland dysfunction; ocular surface; tear film
Description Background: Meibomian gland dysfunction (MGD) is one of the most encountered diseases in the clinical practice but appears to be underappreciated as it does not cause blindness. Meibomian gland dysfunction is a multifactorial and complex disorder of the ocular surface.Aim: This study aims to evaluate the characteristics of the meibomian glands in individuals living with HIV and AIDS undergoing antiretroviral therapy.Setting: The study was conducted at the antiretroviral (ARV) clinic, Mankweng Hospital.Methods: This was a prospective study conducted with 37 HIV and AIDS participants and 20 healthy controls. All participants were assessed using the Ocular Surface Diseases Index (OSDI) score and, tear break-up time and lid margin regularity (using the slit-lamp biomicroscopy). The loss of the meibomian glands was evaluated using the Marx’s line. For this study, this line represented a clinical parameter of meibomian function.Results: The OSDI score was significantly higher in the HIV and AIDS group than that of the control participants (39.95 ± 18.65 and 13.00 ± 9.09, respectively, P  0.05). The tear breakup time (TBUT) for the HIV and AIDS study group was lower than that of the control group (7.95 ± 3.54 and 9.90 ± 3.70, respectively, P  0.05). The HIV and AIDS participants showed greater meibomian gland loss relative to the healthy controls (9.30 ± 4.97 and 5.70 ± 2.1, P  0.05).Conclusion: The loss of eyelid meibomian glands is common in people living with HIV and AIDS in comparison with healthy controls.Contribution: Although there is a decrease in sight-threatening complications in the era of ARVs, ocular surface disorders (OSD) are still commonly found, which may reduce the quality of life of HIV and AIDS individuals.
Publisher AOSIS
Contributor South African Medical Research Council
Date 2024-04-11
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/aveh.v83i1.866
Source African Vision and Eye Health; Vol 83, No 1 (2024); 6 pages 2410-1516 2413-3183
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://avehjournal.org/index.php/aveh/article/view/866/2357 https://avehjournal.org/index.php/aveh/article/view/866/2358 https://avehjournal.org/index.php/aveh/article/view/866/2359 https://avehjournal.org/index.php/aveh/article/view/866/2360
Coverage — — —
Rights Copyright (c) 2024 Solani D. Mathebula, Mologadi D. Ntsoane https://creativecommons.org/licenses/by/4.0