Antimicrobial resistance trends in clinical Escherichia coli and Klebsiella pneumoniae in Ethiopia
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Antimicrobial resistance trends in clinical Escherichia coli and Klebsiella pneumoniae in Ethiopia | |
| Creator | Kitaba, Abera A. Bonger, Zelalem T. Beyene, Degefu Ayenew, Zeleke Tsige, Estifanos Kefale, Tesfa Addis Mekonnen, Yonas Teklu, Dejenie S. Seyoum, Elias Negeri, Abebe A. | |
| Description | Background: Clinicians rely on local antimicrobial resistance pattern data to guide empiric treatment for seriously ill patients when culture and antimicrobial susceptibility testing results are not immediately available.Objective: This study aimed to analyse 5-year trends in antimicrobial resistance profiles of Escherichia coli and Klebsiella pneumoniae isolates.Methods: Bacteriology reports from 2017 to 2021 at the Ethiopian Public Health Institute were analysed retrospectively. Isolates were identified using either the VITEK 2 Compact system, the BD Phoenix M50 instrument, or conventional biochemical tests. Antimicrobial susceptibility testing was conducted using either the Kirby-Bauer disk diffusion method or the VITEK 2 Compact system and BD Phoenix M50 systems available at the time of testing. The Cochran Armitage trend test was employed to test the significance of antimicrobial resistance trends over time. P-values less than 0.05 were considered statistically significant.Results: Of the 5382 bacteriology reports examined, 458 (9%) were on E. coli and 266 (5%) were on K. pneumoniae. Both K. pneumoniae (88%) and E. coli (65%) demonstrated high resistance to extended-spectrum cephalosporins. However, both K. pneumoniae (14%) and E. coli (5%) showed lower rates of resistance to carbapenems compared to other antimicrobials. In K. pneumoniae, resistance to carbapenems (from 0% to 38%; p 0.001) and ciprofloxacin (from 41% to 90%; p 0.001) increased significantly between 2017 and 2021.Conclusion: Both organisms showed very high resistance to broad-spectrum antibiotics. Additionally, K. pneumoniae demonstrated a statistically significant rise in ciprofloxacin and carbapenem resistance.What this study adds: This study emphasises the significance of regular reporting of local antimicrobial resistance patterns as this information can guide appropriate empiric therapy and efforts to address antimicrobial resistance issues. | |
| Publisher | AOSIS | |
| Date | 2024-03-27 | |
| Identifier | 10.4102/ajlm.v13i1.2268 | |
| Source | African Journal of Laboratory Medicine; Vol 13, No 1 (2024); 7 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/2268/2853
https://ajlmonline.org/index.php/ajlm/article/view/2268/2854
https://ajlmonline.org/index.php/ajlm/article/view/2268/2855
https://ajlmonline.org/index.php/ajlm/article/view/2268/2856
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