Antimicrobial resistance trends in clinical Escherichia coli and Klebsiella pneumoniae in Ethiopia

African Journal of Laboratory Medicine

 
 
Field Value
 
Title Antimicrobial resistance trends in clinical Escherichia coli and Klebsiella pneumoniae in Ethiopia
 
Creator Kitaba, Abera A. Bonger, Zelalem T. Beyene, Degefu Ayenew, Zeleke Tsige, Estifanos Kefale, Tesfa Addis Mekonnen, Yonas Teklu, Dejenie S. Seyoum, Elias Negeri, Abebe A.
 
Subject Medical laboratory;Microbiology antimicrobial resistance; retrospective analysis; trend analysis; Escherichia coli; Klebsiella pneumoniae; Ethiopian Public Health Institute; Ethiopia.
Description Background: Clinicians rely on local antimicrobial resistance pattern data to guide empiric treatment for seriously ill patients when culture and antimicrobial susceptibility testing results are not immediately available.Objective: This study aimed to analyse 5-year trends in antimicrobial resistance profiles of Escherichia coli and Klebsiella pneumoniae isolates.Methods: Bacteriology reports from 2017 to 2021 at the Ethiopian Public Health Institute were analysed retrospectively. Isolates were identified using either the VITEK 2 Compact system, the BD Phoenix M50 instrument, or conventional biochemical tests. Antimicrobial susceptibility testing was conducted using either the Kirby-Bauer disk diffusion method or the VITEK 2 Compact system and BD Phoenix M50 systems available at the time of testing. The Cochran Armitage trend test was employed to test the significance of antimicrobial resistance trends over time. P-values less than 0.05 were considered statistically significant.Results: Of the 5382 bacteriology reports examined, 458 (9%) were on E. coli and 266 (5%) were on K. pneumoniae. Both K. pneumoniae (88%) and E. coli (65%) demonstrated high resistance to extended-spectrum cephalosporins. However, both K. pneumoniae (14%) and E. coli (5%) showed lower rates of resistance to carbapenems compared to other antimicrobials. In K. pneumoniae, resistance to carbapenems (from 0% to 38%; p 0.001) and ciprofloxacin (from 41% to 90%; p 0.001) increased significantly between 2017 and 2021.Conclusion: Both organisms showed very high resistance to broad-spectrum antibiotics. Additionally, K. pneumoniae demonstrated a statistically significant rise in ciprofloxacin and carbapenem resistance.What this study adds: This study emphasises the significance of regular reporting of local antimicrobial resistance patterns as this information can guide appropriate empiric therapy and efforts to address antimicrobial resistance issues.
 
Publisher AOSIS
 
Contributor
Date 2024-03-27
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective trend analysis
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/ajlm.v13i1.2268
 
Source African Journal of Laboratory Medicine; Vol 13, No 1 (2024); 7 pages 2225-2010 2225-2002
 
Language eng
 
Relation
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://ajlmonline.org/index.php/ajlm/article/view/2268/2853 https://ajlmonline.org/index.php/ajlm/article/view/2268/2854 https://ajlmonline.org/index.php/ajlm/article/view/2268/2855 https://ajlmonline.org/index.php/ajlm/article/view/2268/2856
 
Coverage Ethiopia 2017-2021 Antimicrobial resistance surveillance secondary data
Rights Copyright (c) 2024 Abera A. Kitaba, Zelalem T. Bonger, Degefu Beyene, Zeleke Ayenew, Estifanos Tsige, Tesfa Addis Kefale, Yonas Mekonnen, Dejenie S. Teklu, Elias Seyoum, Abebe A. Negeri https://creativecommons.org/licenses/by/4.0
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