Antipsychotics-related hyperprolactinaemia among patients with schizophrenia in Maiduguri

South African Journal of Psychiatry

Field Value
Title Antipsychotics-related hyperprolactinaemia among patients with schizophrenia in Maiduguri
Creator Shettima, Falmata B. Wakil, Musa A. Sheikh, Taiwo L. Abdulaziz, Mohammed Wakawa, Ibrahim A. Beida, Omeiza
Subject psychiatry hyperprolactinaemia; antipsychotics; prolactin; schizophrenia; Nigeria
Description Background: Hyperprolactinaemia among patients on antipsychotic medications is generally overlooked due to lack of outwardly visible symptoms, patient resistance to reporting because the symptoms are perceived as shameful, or to clinician’s insufficient knowledge.Aim: The study aimed to evaluate the patterns and correlates of hyperprolactinemia among patients with schizophrenia on antipsychotic medications.Setting: The study was conducted in a psychiatric facility in Maiduguri, Northeastern Nigeria.Methods: A total of 209 patients with schizophrenia were evaluated through a cross-sectional design and assayed for serum prolactin with ELISA Kits. Frequencies and percentages were tabulated for categorical variables. Variables with significant associations with hyperprolactinaemia on chi-square (p  0.05) were subjected to logistic regression analysis.Results: The prevalence of hyperprolactinaemia was 45.9% in all patients on antipsychotic medication. The prevalence because of the use of typical and atypical antipsychotics was 51.5% and 25.0%, respectively. Hyperprolactinaemia was significantly associated with typical antipsychotics (β = 0314, p = 0.002), high overall drug dosage (β = 2.340, p = 0.003), high-dose typical antipsychotics (β = 3.228, p = 0.000), twice daily dosing frequency (β = 2.751, p = 0.001) and polypharmacy (β = 1.828, p = 0.0024).Conclusion: The findings support that patients on typical, high-dose antipsychotic medications and polypharmacy have a high prevalence of hyperprolactinaemia. As hyperprolactinaemia is often undetectable, screening and patient psycho-education on the significance of the signs and symptoms of hyperprolactinaemia is required for necessary clinical intervention.Contribution: The study provides evidence for the rational use of antipsychotic medications in sub-Saharan Africa. 
Publisher AOSIS
Date 2024-02-01
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cross-sectional
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajpsychiatry.v30i0.2133
Source South African Journal of Psychiatry; Vol 30 (2024); 6 pages 2078-6786 1608-9685
Language eng
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Coverage West Africa 2021-2022 Schizophrenia
Rights Copyright (c) 2024 Falmata B. Shettima, Musa A. Wakil, Taiwo L. Sheikh, Mohammed Abdulaziz, Ibrahim A. Wakawa, Omeiza Beida