Retrospective review of bacteriological profiles and antibiogram in a tertiary neonatal unit
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Retrospective review of bacteriological profiles and antibiogram in a tertiary neonatal unit | |
| Creator | Buthelezi, Philile F. Naby, Fathima Kannigan, Yashodhara | |
| Description | Background: Neonatal sepsis remains a major cause of morbidity and mortality. Therefore, early detection and initiation of appropriate empirical antibiotic therapy are crucial.Objectives: The aim of this study was to describe the antibiogram of the neonatal intensive care unit at Grey’s Hospital, a tertiary hospital in KwaZulu-Natal.Method: This was a retrospective descriptive study, reviewing positive cultures from Grey’s Hospital tertiary neonatal intensive care unit (NICU) in KwaZulu-Natal, South Africa for a 3-year period (01 January 2017 to 31 December 2019). All positive cultures from all sites were included.Results: There were 1314 positive organisms cultured. Late-onset sepsis (89.3%) predominated over early-onset sepsis (10.7%). Blood was the source for 55.2% (725/1314) of positive cultures. Of the 1314 organisms cultured, 53.7% (706/1314) were Gram-positive, 45.7% (601/1314) were Gram-negative and 0.5% (7/1314) were Candida species. Klebsiella pneumoniae, 23.5% (313/1314) was the most frequent Gram-negative organism. It was noted to have high resistance to the unit’s first-line antibiotic regimens; 99% were resistant to ampicillin and 92% resistant to gentamicin.Conclusion: Blood cultures yielded most positive results with a predominance of Gram-positive organisms and late-onset sepsis. A significant proportion of the cultured organisms were resistant to the first-line antimicrobials utilised in the unit, ampicillin and gentamicin.Contribution: Ongoing surveillance on positive cultures is recommended to assess the effectiveness of the unit’s current empirical antimicrobial guideline. | |
| Publisher | AOSIS Publishing | |
| Date | 2023-12-08 | |
| Identifier | 10.4102/sajid.v38i1.537 | |
| Source | Southern African Journal of Infectious Diseases; Vol 38, No 1 (2023); 7 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/537/1325
https://sajid.co.za/index.php/sajid/article/view/537/1326
https://sajid.co.za/index.php/sajid/article/view/537/1327
https://sajid.co.za/index.php/sajid/article/view/537/1328
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