Neurological and neuropsychiatric manifestations in hospitalised patients with COVID-19

South African Journal of Psychiatry

Field Value
Title Neurological and neuropsychiatric manifestations in hospitalised patients with COVID-19
Creator Lekpeh, Gondah Salie, Muneeb van den Heuvel, Leigh L. Seedat, Soraya
Subject Medicine; Psychiatry; Public Health COVID-19; neurological manifestations; neuropsychiatric manifestations; respiratory; hospitalised.
Description Background: Although literature globally indicates varied neurological and/or neuropsychiatric manifestations (NNM) and complications associated with coronavirus disease 2019 (COVID-19), information about NNM in infected hospitalised patients on the African continent remains limited.Aim: To describe the presentation of NNM and compare patients with and without NNM considering demographic and clinical profiles, treatment, and outcomes.Setting: Tygerberg Hospital, Cape Town, South Africa.Methods: Retrospective medical record review of the first 100 consecutively admitted COVID-19 patients (64 females, mean age 47.6 years) between March and June 2020.Results: Of the 98 patients included in the analysis, 56.1% had at least one NNM. The most common NNM were myalgia (32.7%), headache (21.4%), loss of smell and/or taste (15.3%), and delirium (10.2%). Patients with and without NNM did not differ with respect to demographic characteristics. Patients with NNM had significantly more constitutional symptoms (p = 0.017) and were more likely to have neurological and/or neuropsychiatric comorbid conditions (10.9% vs. 0.0%, p = 0.033) than those without NNM. Patients without documented NNM were more likely to have abnormalities on chest X-ray (p = 0.009) than those with NNM. Coronavirus disease 2019 related treatment and mortality did not differ between the groups.Conclusion: Neurological and/or neuropsychiatric manifestations were common in hospitalised patients with COVID-19. The results suggest that while COVID-19 patients with NNM may have less of a respiratory phenotype they nonetheless have equivalent mortality rates.Contribution: This study highlights the common NNM in patients with COVID-19 admitted to Tygerberg Hospital early in the pandemic and adds to the growing evidence of COVID-19 NNM.
Publisher AOSIS
Date 2023-11-13
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective medical review
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajpsychiatry.v29i0.2112
Source South African Journal of Psychiatry; Vol 29 (2023); 10 pages 2078-6786 1608-9685
Language eng
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Coverage South Africa, Western Cape; Cape Town; Cape Metropole March 2020 - June 2020 Age; Gender; Ethnicity; COVID-19; Neurological manifestations; Neuropsychiatric manifestations
Rights Copyright (c) 2023 Gondah Lekpeh, Muneeb Salie, Leigh L. van den Heuvel, Soraya Seedat