Sodium restriction and insulin resistance: A review of 23 clinical trials
Journal of Metabolic Health (previously Journal of Insulin Resistance)
| Field | Value | |
| Title | Sodium restriction and insulin resistance: A review of 23 clinical trials | |
| Creator | DiNicolantonio, James J. O'Keefe, James H. | |
| Description | Background: Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance.Aim: This paper aimed to find human clinical studies looking at low-salt diets on markers of glucose and insulin.Methods: We reviewed PubMed using the search terms ‘sodium’, ‘insulin’ and ‘insulin resistance’ and found 23 human clinical studies testing low-salt diets showing negative harms on insulin or glucose.Results: Twenty-three human clinical trials have shown that low-salt diets lead to systemic or vascular insulin resistance, glucose intolerance, elevated fasting insulin and/or elevations in glucose and/or insulin levels after an oral glucose tolerance test.Conclusion: We discovered 23 human clinical studies showing that low-salt diets worsen markers of insulin and glucose. Caution is advised when recommending salt restriction for blood pressure control as this may lead to worsening insulin resistance.Contribution: This review has revealed that low salt diets can induce insulin resistance. | |
| Publisher | AOSIS | |
| Date | 2023-03-14 | |
| Identifier | 10.4102/jir.v6i1.78 | |
| Source | Journal of Metabolic Health; Vol 6, No 1 (2023); 9 pages 2960-0391 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journalofmetabolichealth.org/index.php/jmh/article/view/78/242
https://journalofmetabolichealth.org/index.php/jmh/article/view/78/243
https://journalofmetabolichealth.org/index.php/jmh/article/view/78/244
https://journalofmetabolichealth.org/index.php/jmh/article/view/78/245
https://journalofmetabolichealth.org/index.php/jmh/article/downloadSuppFile/78/73
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