A retrospective analysis of concurrent chemoradiation for squamous cell carcinoma of the anus in Johannesburg
SA Journal of Oncology
| Field | Value | |
| Title | A retrospective analysis of concurrent chemoradiation for squamous cell carcinoma of the anus in Johannesburg | |
| Creator | Tshoeu, Phemelo Sharma, Vinay Ruff, Paul | |
| Description | Background: Anal cancer is a major cause of mortality and morbidity in low- and middle-income countries (LMICs).Aim: A retrospective analysis to understand presentation and outcomes of patients with anal cancer, who were treated with a curative intent.Setting: A radiation oncology unit in quaternary level hospital in South Africa.Methods: Medical records of patients with invasive squamous cell carcinoma (SCC) of the anal canal who were treated between 2014 and 2019 were reviewed with follow-up until June 2021. The 2D-radiotherapy planning and delivery techniques were used to a dose of 50 Gy, with a boost dose of 6 Gy – 10 Gy for patients with residual disease and concurrent chemotherapy.Results: Eighty-four patients were included in the analysis. Median age was 45 years (range: 25–73 years), 75% were female patients, 80% of the cohort was human immunodeficiency virus (HIV)-positive, and 17% with a CD4 count below 200 cells/mm3. Eighty-seven percent had locally advanced stage three disease. Concurrent 5-fluorouracil (5-FU) and mitomycin C-based chemotherapy was given in four patients, while 50% had 5-FU plus cisplatin and 16% had radiotherapy alone. Complete clinical response was observed in 54 out of 66 evaluable patients (81.8%) at 6 months post-chemoradiation. Overall survival at 2 years could not be determined because of a significant loss to follow-up rate.Conclusion: A high HIV-postive rate and an advanced disease stage were observed among cohorts with anal canal SCC treated with a definitive curative intent. Tumour response rates at 6 months were favourable although the 2-year overall survival could not be established.Contribution: This study contributes to the growing body of research on anal cancer outcomes in LMICs. | |
| Publisher | AOSIS | |
| Date | 2023-09-19 | |
| Identifier | 10.4102/sajo.v7i0.270 | |
| Source | South African Journal of Oncology; Vol 7 (2023); 7 pages 2523-0646 2518-8704 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajo.org.za/index.php/sajo/article/view/270/778
https://sajo.org.za/index.php/sajo/article/view/270/779
https://sajo.org.za/index.php/sajo/article/view/270/780
https://sajo.org.za/index.php/sajo/article/view/270/781
|
|
ADVERTISEMENT
