Gastrointestinal stromal tumours in patients presenting to an academic hospital in South Africa
SA Journal of Oncology
| Field | Value | |
| Title | Gastrointestinal stromal tumours in patients presenting to an academic hospital in South Africa | |
| Creator | Robertson, Barbara M. Chinnery, Galya E. Locketz, Michael L. Parker, Michelle Vorster, Alvera A. Ramesar, Raj Panieri, Eugenio Hunter, Alistair J. | |
| Description | Background: Published information on African patients with gastrointestinal stromal tumours (GISTs) is limited.Aim: The aim of this study was to review patient and tumour characteristics, and treatment, for a cohort of African patients and compare findings to studies from other centres.Setting: Groote Schuur Hospital, South Africa.Methods: Data were collected on all patients referred to Groote Schuur Hospital (GSH) during the period October 2003 to November 2019, including demographics, tumour characteristics and treatment outcomes.Results: There were 124 patients in total. There was a slight male predominance (55.6%) and the median age was 56 years. The most common primary tumour sites were the stomach (66.2%) and small bowel (21.8%) with a median primary tumour diameter of 95.5 mm. Mutational analysis was conducted for 39 patients with 66.7% of these patients having mutations in KIT exon 11. The primary tumour was resected in 72 patients, with 48.6% having high-risk tumours according to the National Institutes of Health (NIH) risk assessment. The 10-year overall survival (OS) values for patients by risk group were 83% (very low and low risk), 73% (intermediate risk) and 66% (high risk). The disease control rate for patients treated with imatinib was 84.6%. The median progression-free survival (PFS) for patients treated with imatinib for palliation was 23 months with OS of 31 months.Conclusion: In contrast to patients from other centres, our patients were younger and had larger tumours.Contribution: The distribution of primary tumour site, mutational analysis and response to imatinib was consistent with the literature. | |
| Publisher | AOSIS | |
| Date | 2023-06-13 | |
| Identifier | 10.4102/sajo.v7i0.265 | |
| Source | South African Journal of Oncology; Vol 7 (2023); 9 pages 2523-0646 2518-8704 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajo.org.za/index.php/sajo/article/view/265/768
https://sajo.org.za/index.php/sajo/article/view/265/769
https://sajo.org.za/index.php/sajo/article/view/265/770
https://sajo.org.za/index.php/sajo/article/view/265/771
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