UPLC–QTOF/MS tentative identification of phytochemicals from Vernonia amygdalina Delile acetone and ethanol leaf extracts

Journal of Medicinal Plants for Economic Development

 
 
Field Value
 
Title UPLC–QTOF/MS tentative identification of phytochemicals from Vernonia amygdalina Delile acetone and ethanol leaf extracts
 
Creator Mkhonto, Christeldah Makananise, Vusani Sagbo, Idowu J. Mashabela, Madonna N. Ndhlovu, Peter T. Kubheka, Bongani P. Otang-Mbeng, Wilfred
 
Subject — Compounds; UPLC; metabolites; sesquiterpenes; phytochemicals.
Description Background: Vernonia amygdalina Delile is a woody medicinal plant that is commonly used in various folklore medicine in South Africa against helminthic, protozoal and bacterial infections. Despite its high medicinal values, the chemical profile of this plant has not been fully elucidated and remains unclassified.Aim: The present study reports the tentative identification of untargeted metabolite profiling from V. amygdalina Delile acetone and ethanol leaf extracts.Setting: The study took place in the Nkomazi municipality which is located in the eastern part of the Ehlazeni district municipality of the Mpumalanga province.Methods: Metabolites were identified using ultraperformance liquid chromatography (UPLC) method coupled with quadrupole time of flight mass spectrometry (qTOF/MS).Results: The UPLC-qTOF-MS analysis tentatively revealed the presence of prominent metabolites, 17 of which were identified in acetone extracts and 12 in the ethanol extracts of V. amygdalina Delile. The identified metabolites included compound classes such as terpenoids which were highest in the acetone extracts (23.53%) and flavonoids which were highest in the ethanol extracts (25%).Conclusion: The findings reveal several significant bioactive compounds which may contribute to the development of new antifungal drugs.Contribution: The results showed significant chemical differences between both extracts of the plant in the profiles. The findings revealed several significant bioactive compounds which may contribute to the development of new antifungal drugs.
 
Publisher AOSIS Publishing
 
Contributor
Date 2023-06-06
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jomped.v7i1.181
 
Source Journal of Medicinal Plants for Economic Development; Vol 7, No 1 (2023); 8 pages 2616-4809 2519-559X
 
Language eng
 
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https://jomped.org/index.php/jomped/article/view/181/633 https://jomped.org/index.php/jomped/article/view/181/634 https://jomped.org/index.php/jomped/article/view/181/635 https://jomped.org/index.php/jomped/article/view/181/636
 
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Rights Copyright (c) 2023 Christeldah Mkhonto, Vusani Makananise, Idowu J. Sagbo, Madonna N. Mashabela, Peter T. Ndhlovu, Bongani P. Kubheka, Wilfred Otang-Mbeng https://creativecommons.org/licenses/by/4.0
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