Effect of HIV on mortality among hospitalised patients in South Africa

Southern African Journal of HIV Medicine

Field Value
Title Effect of HIV on mortality among hospitalised patients in South Africa
Creator Lamprecht, Dirk J. Martinson, Neil Variava, Ebrahim
Subject Epidemiology in-hospital mortality; cause of death; HIV; mortality rate; people living with HIV; tuberculosis-related mortality
Description Background: HIV and AIDS continues to impose substantial healthcare challenges in sub-Saharan Africa, but there are limited local data comparing inpatient outcomes between people with HIV (PLWH) and those uninfected.Objectives: To compare cause-specific mortality among hospitalised adolescents and adults, stratified by HIV-serostatus.Method: A cross-sectional analysis was performed, analysing cause-specific inpatient mortality data and total admissions, from 01 January 2017 to 30 June 2020, at Tshepong Hospital, North West province, South Africa.Results: The overall inpatient mortality rate decreased from 14.5% (95% confidence interval [CI]: 13.4–16.0) in 2017, to 11.3% (95% CI: 10.6–11.9) in 2020; P  0.001. People living with HIV accounted for 53.9% (n = 2342) of inpatient deaths, 22.6% (n = 984) were HIV-seronegative patients and 23.5% (n = 1020) patients with unknown HIV-serostatus. People with HIV died at younger ages (median: 44 years, interquartile range [IQR]: 35.8–54.2) compared to HIV-seronegative inpatients (median: 64.4 years, IQR: 55.5–73.9); P  0.001. Leading causes of death were pneumonia (19.9%, n = 863), then pulmonary and extrapulmonary tuberculosis (15.0%, n = 654). People with HIV who had CD4+ counts 350 cells/mL or viral load ≥ 1000 copies/mL had increased risk of death from tuberculosis compared to virally suppressed patients (adjusted relative risk: 2.10 [95% CI: 1.44–3.04, P  0.009] and 1.56 [95% CI: 1.22–2.00, P  0.001]).Conclusion: Our study, conducted in a regional hospital in South Africa, showed PLWH had higher mortality rates and died at younger ages compared to HIV-seronegative patients.
Publisher AOSIS
Contributor nil
Date 2023-04-26
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cross sectional analysis; secondary analysis
Format text/html application/epub+zip text/xml application/pdf application/pdf
Identifier 10.4102/sajhivmed.v24i1.1477
Source Southern African Journal of HIV Medicine; Vol 24, No 1 (2023); 9 pages 2078-6751 1608-9693
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajhivmed.org.za/index.php/hivmed/article/view/1477/3030 https://sajhivmed.org.za/index.php/hivmed/article/view/1477/3031 https://sajhivmed.org.za/index.php/hivmed/article/view/1477/3032 https://sajhivmed.org.za/index.php/hivmed/article/view/1477/3034 https://sajhivmed.org.za/index.php/hivmed/article/view/1477/3033
Coverage North-West Province, South Africa 2017 until 2020 Age; Gender; Cause of death; HIV-serostatus
Rights Copyright (c) 2023 Dirk J. Lamprecht, Neil Martinson, Ebrahim Variava https://creativecommons.org/licenses/by/4.0