Outcomes of breast conserving therapy: Recurrence, imaging findings and histological correlation

SA Journal of Radiology

Field Value
Title Outcomes of breast conserving therapy: Recurrence, imaging findings and histological correlation
Creator Sondezi, Marara N. Buccimazza, Ines Madlala, Ntombizakhona B.
Subject Radiology; women's imaging; women's health; breast imaging; specialised breast surgery; mammography breast conserving surgery; breast conserving therapy; ipsilateral breast tumour recurrence; breast cancer recurrence; lumpectomy; wide local excision; quadrantectomy; breast mass; breast cancer; radiotherapy
Description Background: Breast conserving therapy (BCT) is the mainstay therapy in patients with early breast cancer and selected patients with locally advanced breast cancer. No formal audit has been performed on BCT at our institution.Objectives: To determine the incidence and risk factors for ipsilateral breast tumour recurrence (IBTR). Study the imaging features of IBTR. Determine adherence to the proposed annual mammographic surveillance schedule.Method: Clinical, radiological and histopathological records of patients who underwent BCT from 01 January 2011 to 31 December 2015 were reviewed. Patients were followed up for at least 5 years.Results: Ninety-two patients were included in the study with a mean age of 54.3 years. Eighty of the 92 (87.0%) patients were imaged within 1-year post-BCT. Ipsilateral breast tumour recurrence was 6/92 (6.5%) with mean time to IBTR of 34.4 months. One of the 92 (1.0%) patients had a contralateral metachronous recurrence with no IBTR and 11/92 (12.0%) had distant metastases only. Pathological tumour size and extent (pT2) (68.5%) and pathological lymph node (pN0) (65.2%) were the most common locoregional staging. Infiltrating ductal carcinoma was the most common histological type (88%). Age 35 years was associated with breast cancer recurrence (p  0.01). Imaging findings of recurrence were microcalcification (odds ratio [OR]: 4), asymmetric density (OR: 4) and skin thickening (OR: 2.5).Conclusion: The occurrence of IBTR following BCT in our unit is acceptable and comparable to local and international units. The accuracy of assessing the post-BCT breast for IBTR is in keeping with international standards.Contribution: Improved radiological imaging interpretation of the post-BCT breast.
Publisher AOSIS
Contributor Ines Buccimazza, Breast and Endocrine Unit, Inkosi Albert Luthuli Central Hospital Ntombizakhona Madlala, KZN Breast Centre of Excellence, Radiology, IALCH Catherine Connolly, School of Mathematics, Statistics and Computer Science, UKZN
Date 2023-04-20
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Qualitative retrospective study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajr.v27i1.2592
Source South African Journal of Radiology; Vol 27, No 1 (2023); 9 pages 2078-6778 1027-202X
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajr.org.za/index.php/sajr/article/view/2592/3362 https://sajr.org.za/index.php/sajr/article/view/2592/3363 https://sajr.org.za/index.php/sajr/article/view/2592/3364 https://sajr.org.za/index.php/sajr/article/view/2592/3365
Coverage South Africa; KwaZulu-Natal; Durban 1 January 2011 - 31 December 2015 Age; Tumour size; Nodal staging; Hormonal status; Histological subtype; Family history; BRCA status; auxiliary lymph node status; Ultrasound; mammogram; MRI findings of recurrence; histopathological reports; radiotherapy;
Rights Copyright (c) 2023 Marara N. Sondezi, Ines Buccimazza, Ntombizakhona B. Madlala https://creativecommons.org/licenses/by/4.0