Imaging in Van Wyk Grumbach syndrome: An uncommon presentation of hypothyroidism

SA Journal of Radiology

Field Value
Title Imaging in Van Wyk Grumbach syndrome: An uncommon presentation of hypothyroidism
Creator Sherwani, Poonam Nandolia, Khanak K. Joshi, Kirti Lourembam, Radhapyari
Subject General Practice:education galactorrhoea; hypothyroidism; isosexual precocious puberty; pituitary; ovarian mass; thyroid stimulating hormone (TSH); per vagina; Van Wyk Grumbach syndrome (VWGS)
Description Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy.Contribution: Typical clinical and radiological features of the syndrome are reported, which helps in the early diagnosis and management, henceforth avoiding the associated complications. 
Publisher AOSIS
Date 2023-03-15
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajr.v27i1.2572
Source South African Journal of Radiology; Vol 27, No 1 (2023); 4 pages 2078-6778 1027-202X
Language eng
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Coverage India — —
Rights Copyright (c) 2023 Poonam Sherwani, Khanak K. Nandolia, Kirti Joshi, Radhapyari Lourembam