Malaria an opportunistic infection in HIV/AIDS patients? – A Nigerian experience
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Malaria an opportunistic infection in HIV/AIDS patients? – A Nigerian experience | |
| Creator | Enuma, Joseph N. Sanni, Felix O. Matur, Malau B. Jean, Njab E. Erhabor, Tosan Egbulefu, Iheukwumere I. | |
| Description | Background: HIV and malaria interact at the level of the host’s susceptibility to infection, but little is known about the effect of HIV on malaria infection in Nigeria.Objective: This study estimated the prevalence of malaria parasitaemia and its relationship with HIV immunodeficiency.Methods: This cross-sectional study was conducted in two hospitals in Abuja, Nigeria between October 2012 and March 2013 among 600 respondents, comprising 200 HIV-negative controls, 200 HIV-positive patients on antiretroviral therapy (ART), and 200 HIV-positive patients not on ART. Malaria parasites, malaria density and absolute CD4 counts were carried out on all three groups. Participants with CD4 counts below 350 cells/mm3 were considered immunocompromised and likely to develop opportunistic infections.Results: Most study participants were aged 21–40 years (65.2%). The mean CD4 counts of HIV-positive patients not on ART (300 ± 211 cells/mm3) and those on ART (354 cells/mm3) were significantly lower than among controls (834 cells/mm3) (p 0.001). Malaria prevalence was not statistically different between the controls (44.5%), patients on ART (40.5%), and those not on ART (39.5%) (p = 0.562). Compared to 7% immunodeficiency among controls, 56% of patients on ART and 65.5% of those not on ART had a CD4 count 350 cells/mm3 (p 0.001). The prevalence of malaria parasitaemia among immunodeficient individuals (42.4%) was similar to prevalence among those with CD4 counts 350 cells/mm3 (40.8%; p = 0.695).Conclusion: These findings suggest that malaria parasitaemia is not an opportunistic infection among HIV-positive individuals in Nigeria. | |
| Publisher | AOSIS | |
| Date | 2022-11-24 | |
| Identifier | 10.4102/ajlm.v11i1.1842 | |
| Source | African Journal of Laboratory Medicine; Vol 11, No 1 (2022); 6 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/1842/2478
https://ajlmonline.org/index.php/ajlm/article/view/1842/2479
https://ajlmonline.org/index.php/ajlm/article/view/1842/2480
https://ajlmonline.org/index.php/ajlm/article/view/1842/2481
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