Microbial keratitis: Causative organisms, susceptibilities and trends at a tertiary eye hospital in South Africa

African Vision and Eye Health

Field Value
Title Microbial keratitis: Causative organisms, susceptibilities and trends at a tertiary eye hospital in South Africa
Creator Anderson, Craig D. Rees, Nicki Koetsie, Karen Rose, André Makgotloe, Aubrey
Subject ophthalmology; microbiology eye; infection; keratitis; microbial; antibiotics
Description Background: Microbial keratitis is a sight-threatening disease. Empiric management is based on current regional microbial sensitivity patterns.Aim: This study aimed to describe the demographics and microbial patterns of keratitis at St John Eye Hospital and compare it with data from the same centre 10 years prior.Setting: A tertiary eye care centre in Soweto, South Africa.Methods: A retrospective cross-sectional study of the microbiological reports of patients treated for microbial keratitis between 01 January 2018 and 31 December 2018.Results: The median age of patients was 42 years (interquartile range [IQR]: 3–77) with a male predominance of 57.0% (n = 65/113). Culture positivity rate was 63.0% (n = 84/133). There was a predominance of Gram-positive organisms of 63.0% (n = 84/133). The most common Gram-positive organism was coagulase-negative Staphylococcus (CNS) (32.0%, 42/133), and the most common Gram-negative organism was Pseudomonas aeruginosa (6.0%, 8/133). Other common organisms were Staphylococcus aureus (14.0%, 18/133), Streptococcus pneumoniae (9.0%, 12/133) and Streptococcus viridans (5.0%, 6/133). Commonly used fluoroquinolones ciprofloxacin and moxifloxacin had resistance of 4.2% and 10.0%, respectively. Gentamicin had a resistance of 5.8%. Culture positivity rate increased compared to 2008 from 52% to 63%. There was an increase from 2008 to 2018 of Pseudomonas aeruginosa from 2% to 6%. There was little change in antibiotic resistance profiles between the two study periods (2008 and 2018).Conclusion: Culture positivity rate has increased at our institution and suggests improvements in detecting organisms and antibiotic susceptibilities. There does not seem to be any change in the susceptibilities of organisms between the study periods; therefore, it suggests current empiric management remains appropriate.
Publisher AOSIS
Contributor National Health Laboratory Service
Date 2022-10-27
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective cross-sectional
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/aveh.v81i1.778
Source African Vision and Eye Health; Vol 81, No 1 (2022); 6 pages 2410-1516 2413-3183
Language eng
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https://avehjournal.org/index.php/aveh/article/view/778/1994 https://avehjournal.org/index.php/aveh/article/view/778/1995 https://avehjournal.org/index.php/aveh/article/view/778/1996 https://avehjournal.org/index.php/aveh/article/view/778/1997
Coverage Africa; South Africa; Gauteng 2008 and 2018 age; gender;
Rights Copyright (c) 2022 Craig D. Anderson, Nicki Rees, Karen Koetsie, André Rose, Aubrey Makgotloe https://creativecommons.org/licenses/by/4.0