Differentiation between various types and subtypes of intracranial meningiomas with advanced MRI

SA Journal of Radiology

Field Value
Title Differentiation between various types and subtypes of intracranial meningiomas with advanced MRI
Creator Panigrahi, Mousam Bodhey, Narendra K. Pati, Saroj K. Hussain, Nighat Sharma, Anil K. Shukla, Arvind K.
Subject Radiology, Advanced MRI, meningioma; ASL; T1 perfusion; ADC; DTI
Description Background: Meningiomas are the most prevalent of all intracranial tumours. Although they are mostly benign, about 20% of meningiomas are atypical or malignant. Knowledge of their histologic grade can be clinically useful while planning surgery.Objectives: To differentiate between various grades and subtypes of meningiomas with advanced MR parameters.Method: We assessed the advanced MR imaging characteristics of 27 histopathologically confirmed meningiomas on a 3T MRI, of which 23 were grade I meningiomas (2 fibroblastic, 9 meningothelial, 9 transitional, 3 unspecified) and 4 were grade II/III meningiomas (2 atypical, 1 papillary, 1 anaplastic). Analysis of the ADC, FA, λ1, λ2, λ3 and mean diffusivity was performed using standard post-processing software.Results: The mean size of atypical meningiomas (5.9 cm ± 0.7 cm) was significantly higher (p = 0.038, 95% confidence interval [CI]) than that of typical meningiomas (4.6 cm ± 1.6 cm) with a cut-off value of 6.05 cm (75% sensitivity and 87% specificity). The mean cerebral blood flow (CBF) (ASL) of atypical meningiomas (286.70 ± 8.06) was significantly higher (p = 0.0000141, 95% CI) than that of typical meningiomas (161.09 ± 87.04) with a cut-off value of 276.75 (66.7% sensitivity and 75% specificity). Among the typical meningiomas, transitional subtypes had the lowest ADC. High FA and planar coefficient (CP) values and low λ3 and spherical coefficient (CS) values were seen in fibroblastic meningiomas. Fibroblastic meningiomas also showed the lowest vascularity among typical meningiomas.Conclusion: Tumour size and ASL perfusion are two parameters that could differentiate between typical and atypical meningiomas while ADC, FA, λ3, CP, CS, rCBF and rCBV may be helpful in distinguishing different subtypes of typical meningiomas.
Publisher AOSIS
Contributor Nonfunded thesis study
Date 2022-10-26
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Prospective observational study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajr.v26i1.2480
Source South African Journal of Radiology; Vol 26, No 1 (2022); 9 pages 2078-6778 1027-202X
Language eng
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https://sajr.org.za/index.php/sajr/article/view/2480/3270 https://sajr.org.za/index.php/sajr/article/view/2480/3271 https://sajr.org.za/index.php/sajr/article/view/2480/3272 https://sajr.org.za/index.php/sajr/article/view/2480/3273
Coverage India March 2019-December 2020 Institution based cases of intracranial meningiomas
Rights Copyright (c) 2022 Mousam Panigrahi, Narendra K. Bodhey, Saroj K. Pati, Nighat Hussain, Anil K. Sharma, Arvind K. Shukla https://creativecommons.org/licenses/by/4.0