The necessity of bilateral staging bone marrow examinations for paediatric solid tumours

SA Journal of Oncology

Field Value
Title The necessity of bilateral staging bone marrow examinations for paediatric solid tumours
Creator van Marle, Anne-Cecilia Coetzee, Ilse Britz, Wynand Eichbauer, Jade Smith, Marguerité van Gend, Marli van der Westhuizen, Helen Vorster, Rièlle Haupt, Leriska
Subject Paediatric Oncology; Haematology bone marrow aspirate and trephine biopsy; solid tumour; staging; metastases; childhood cancer
Description Background: Bone marrow aspirates and trephine biopsies (BMATs) form an important part of staging to detect bone marrow metastases of both haematological and nonhaematological neoplasms.Aim: The study’s primary aim was to determine whether it is necessary to perform bilateral BMATs on paediatric cancer patients as opposed to unilateral BMATs for the staging of solid tumours.Setting: The Paediatric Oncology Unit at Universitas Academic Hospital (UAH) in Bloemfontein, Free State, South Africa.Methods: A retrospective descriptive study was performed using laboratory reports from 01 January 2015 to 31 December 2019. Data were collected and reported on regarding the total number of staging BMATs performed, the average length of the trephine biopsies, the number of BMATs used for primary diagnosis, the number of bone marrow specimens where metastases were detected (left, right or both), the type of primary cancer and demographic information.Results: One hundred and eighteen patients were included for interpretation. Bone marrow metastases were detected in 28 patients, of which five patients had discrepant left and right results. These five cases included nephroblastoma (n = 2), Hodgkin lymphoma (n = 2) and a germ cell tumour (n = 1).Conclusion: Discrepant results were found in five cases (n = 28; 17.8%). Ultimately, the clinical implication of incorrectly staging solid tumours outweighs the small risks and discomfort of a bilateral bone marrow biopsy.
Publisher AOSIS
Date 2022-09-27
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective descriptive study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v6i0.242
Source South African Journal of Oncology; Vol 6 (2022); 6 pages 2523-0646 2518-8704
Language eng
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Coverage Central South Africa 2015-2019 Paediatric oncology patients
Rights Copyright (c) 2022 Anne-Cecilia van Marle, Ilse Coetzee, Wynand Britz, Jade Eichbauer, Marguerité Smith, Marli van Gend, Helen van der Westhuizen, Rièlle Vorster, Leriska Haupt