Testicular germ cell cancer in Africa: A survey on patterns of practice

SA Journal of Oncology

Field Value
Title Testicular germ cell cancer in Africa: A survey on patterns of practice
Creator Burger, Henriette Rick, Tara Spies, Pieter Cassel, Ayun Vanderpuye, Verna Incrocci, Luca
Subject Radiation Oncology; Urology; Clinical Oncology testicular germ cell tumour; testicular cancer; Africa; multidisciplinary management; quality improvement
Description Background: Testicular germ cell tumours (GCTs) are rare malignancies most prevalent in 15–40-year-old men. Incidence rates of testicular cancer on a global level show marked geographic variation with higher incidence rates reported in predominantly Caucasian populations. African data on GCT management show low incidence rates but an advanced stage at presentation and high mortality rates.Aim: The aim of the study was to explore patterns of practice in the management of testicual GCTs.Setting: The study was conducted in an African oncology care setting.Methods: A cross-sectional web-based survey was distributed to doctors or nurses providing oncology care for patients with testicular GCT in Africa. Data on staging procedures, chemotherapy and radiotherapy (RT) treatment schedules across institutions are reported and discussed in the context of international treatment guidelines and local resources.Results: Eleven African countries contributed data. Epidemiological estimates were received from 20 institutions and management and outcome data from 18 institutions. The estimated ratio of seminoma to non-seminoma was 1:1.3. The stage at presentation was tumour-node-metastases-serum marker (TNM-S) Stage III at half of the institutions surveyed. Chemotherapy regimens mostly followed international guidelines, but certain essential drugs were not consistently accessible at all centres. Radiotherapy services were available to all but one respondent, with three-dimensional planning being widely used. There was marked variation in RT doses and treatment fields.Conclusion: The resources to effectively manage testicular GCT appear to be accessible to most institutions surveyed. Regional management guidelines, sharing of clinical expertise within Africa through online platforms and centralised data collection on epidemiology, management and treatment efficacy are advocated to better allocate resources and improve the outcomes reported in this rare but potentially curable condition.
Publisher AOSIS
Contributor AORTIC
Date 2022-09-15
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cross-sectional web-based survey of clinicians
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v6i0.241
Source South African Journal of Oncology; Vol 6 (2022); 8 pages 2523-0646 2518-8704
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajo.org.za/index.php/sajo/article/view/241/636 https://sajo.org.za/index.php/sajo/article/view/241/637 https://sajo.org.za/index.php/sajo/article/view/241/638 https://sajo.org.za/index.php/sajo/article/view/241/639
Coverage Sub-Saharan Africa June 2021 Doctors or nurses providing oncology care for patients with testicular cancer in Africa
Rights Copyright (c) 2022 Henriette Burger, Tara Rick, Pieter Spies, Ayun Cassel, Verna Vanderpuye, Luca Incrocci https://creativecommons.org/licenses/by/4.0