Factors associated with bone marrow involvement in lymphoma staging bone marrow examination: A South African single-centre retrospective study

SA Journal of Oncology

Field Value
Title Factors associated with bone marrow involvement in lymphoma staging bone marrow examination: A South African single-centre retrospective study
Creator Lohlun, Robert K. Chapanduka, Zivanai C.
Subject Pathology; Haematopathology lymphoma staging; bone marrow involvement; HIV
Description Background: Accurate detection of bone marrow involvement (BMI) in lymphoma is important as it signifies stage 4 disease. Staging bone marrow examination (BME), therefore, influences treatment decisions and prognostication. The prevalence of BMI depends on multiple factors at presentation including lymphoma subtype, age, sex, human immunodeficiency virus (HIV) status and haematological parameters.Aim: To determine risk factors for BMI in lymphoma staging.Setting: The study was conducted in the department of haematological pathology, Tygerberg Hospital, Cape Town, South Africa.Methods: Retrospective cross-sectional descriptive study in adult patients, reviewing BMI and associated parameters, during their initial lymphoma staging procedure between 2016 and 2019.Results: Of a total of 387 lymphoma staging cases that were evaluated, 30.0% of them showed BMI. Diffuse large B-cell lymphoma, Hodgkin lymphoma and high-grade B-cell lymphoma were the most frequent subtypes diagnosed. The highest prevalence of BMI was in low-grade lymphomas. There was a statistically significant association between BMI and advanced age, pancytopenia and bicytopenia (anaemia with leucopenia, anaemia with thrombocytopenia or leucopenia with thrombocytopenia). Bicytopenia and pancytopenia showed high positive predictive values of BMI, respectively, 61.0% and 69.0%. Human immunodeficiency virus positivity (34.6%) was not predictive of BMI across all lymphoma subtypes. Normal blood counts had a high negative predictive value for BMI.Conclusion: BME remains an important part of lymphoma staging with 30.0% of all lymphomas showing BMI.
Publisher AOSIS
Contributor N/A
Date 2022-08-23
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective cross-sectional descriptive study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v6i0.211
Source South African Journal of Oncology; Vol 6 (2022); 8 pages 2523-0646 2518-8704
Language eng
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https://sajo.org.za/index.php/sajo/article/view/211/624 https://sajo.org.za/index.php/sajo/article/view/211/625 https://sajo.org.za/index.php/sajo/article/view/211/626 https://sajo.org.za/index.php/sajo/article/view/211/627
Coverage Africa; South Africa; Western Cape; Cape Town 2016-2019 Adults; Lymphoma staging bone marrow examination
Rights Copyright (c) 2022 Robert K. Lohlun, Zivanai C. Chapanduka https://creativecommons.org/licenses/by/4.0