Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana

Southern African Journal of HIV Medicine

Field Value
Title Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana
Creator Karugaba, Grace Thupayagale-Tshweneagae, Gloria Moleki, Mary M. Mabikwa, Onkabetse V. Matshaba, Mogomotsi
Subject Health; Psychology; Education perinatal HIV; young adulthood; health-related quality of life; ART; Botswana
Description Background: Due to the successful antiretroviral therapy (ART) programme in Botswana, large numbers of perinatally HIV-infected adolescents are emerging into young adulthood. Young adulthood is a critical period of human development. However, there is lack of information on the factors affecting the health-related quality of life (HRQOL) of young adults living with perinatally acquired HIV (YALPH) in Botswana.Objectives: The objective of this study was to assess the HRQOL and its determinants among YALPH who were enrolled on ART at Botswana-Baylor Children’s Clinical Centre of Excellence in Gaborone, Botswana.Method: A cross-sectional study assessed the HRQOL of 509 YALPH aged 18–30 years using the WHOQOL-HIV BREF. Data about other variables of interest were abstracted from medical records. Bivariate analyses were performed using t and Chi-square tests to determine the associations between demographic and clinical variables and general HRQOL. The variables that were associated with the general HRQOL at P-value 0.1 were included in the multivariable analysis using the logistic regression approach.Results: The majority of participants had good general HRQOL (78.4%). The highest mean HRQOL score was in the Physical domain (5.4 [± 2.9]) and the lowest in the Environment domain (13.8 [± 2.7]). The factors that were significantly associated with the general HRQOL included: level of education attained (P = 0.012), employment status (P = 0.069), viral load suppression (P = 0.073) and self-reported illness (P = 0.001).Conclusion: Interventions that effectively increase educational attainment, employment opportunities, ART adherence, and prevention or management of illness are needed to promote good HRQOL among YALPH in Botswana.
Publisher AOSIS
Date 2022-04-29
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — survey
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v23i1.1362
Source Southern African Journal of HIV Medicine; Vol 23, No 1 (2022); 10 pages 2078-6751 1608-9693
Language eng
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Rights Copyright (c) 2022 Grace Karugaba, Gloria Thupayagale-Tshweneagae, Mary M. Moleki, Onkabetse V. Mabikwa, Mogomotsi Matshaba