Age-related differences in the vascular function and structure of South Africans living with HIV

Southern African Journal of HIV Medicine

Field Value
Title Age-related differences in the vascular function and structure of South Africans living with HIV
Creator Louwrens, Anisca Fourie, Carla M.T. Botha-Le Roux, Shani Breet, Yolandi
Subject Physiology; HIV; CVD arterial stiffness; carotid intima-media thickness; antiretroviral treatment; early vascular ageing; multi-morbidity
Description Background: As the life expectancy of people living with the HIV increases because of antiretroviral treatment (ART), their risk for vascular co-morbidities and early vascular ageing (EVA) also increases.Objective: We aimed to investigate whether HIV infection relates to vascular structure and function in black South African adults and whether this relationship is age dependent.Method: This cross-sectional study carried out in urban and rural areas of North West province, South Africa, included 572 age- and sex-matched people living with HIV (PLWH) and without HIV. Participants from the EndoAfrica study and PURE study were stratified according to tertiles of age. Measures of vascular structure (carotid intima-media thickness) and function (carotid-femoral pulse wave velocity, central systolic blood pressure, central pulse pressure and pulse pressure amplification) were determined.Results: Blood pressure measures were lower in PLWH compared with their controls (all P ≤ 0.001), especially in the younger and middle-aged groups (all P ≤ 0.031), whilst vascular measures did not differ (all P ≥ 0.611). In multivariate linear regression analyses, vascular measures were not associated with a HIV- positive status in either the total or any of the age groups.Conclusion: Black South Africans living with HIV have a less adverse blood pressure profile than their counterparts without HIV. The HIV-positive status was not associated with measures of vascular structure or function in any age group. The results suggest that HIV does not contribute to EVA in this population; however, further longitudinal investigation is warranted.
Publisher AOSIS
Date 2022-02-24
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Research study; Cross sectional; human participants data collection
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v23i1.1335
Source Southern African Journal of HIV Medicine; Vol 23, No 1 (2022); 12 pages 2078-6751 1608-9693
Language eng
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Coverage South African HIV; Cardiovascular disease; Early vascular ageing HIV; cardiovascular risk; age
Rights Copyright (c) 2022 Anisca Louwrens, Carla M.T. Fourie, Shani Botha-Le Roux, Yolandi Breet