Extranodal presentation of a lymphoma with precursor B-cell phenotype and translocation t(8;14) in South Africa
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Extranodal presentation of a lymphoma with precursor B-cell phenotype and translocation t(8;14) in South Africa | |
| Creator | Hodkinson, Katherine E. Perner, Yvonne Glencross, Deborah K. Wiggill, Tracey Botha, Adam Poole, Janet | |
| Description | Introduction: A rare entity of a B-cell malignancy with precursor B-cell phenotype and concomitant translocation t(8;14) or variant MYC translocation exists. These cases show clinical, pathological and molecular overlap between precursor B-lymphoblastic leukaemia or lymphoma and Burkitt leukaemia or lymphoma (BLL).Case presentation: We report a case from February 2019 at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, of a 9-month-old infant with a predominantly extracranial soft tissue mass showing extradural extension. There was no involvement of the peripheral blood or bone marrow. Fine needle aspiration and Tru-Cut biopsy of the soft tissue scalp mass showed the tumour to be of precursor B-cell phenotype. Contrastingly, an immunophenotypic assessment revealed a high S-phase fraction and raised concern for BLL. This prompted testing for the translocation t(8;14) by fluorescence in-situ hybridisation analysis, which confirmed this aberration.Management and outcome: Based on the published experience of other centres, the patient was initiated on a BLL protocol. Despite an excellent clinical response, the patient succumbed to neutropenic sepsis six months after diagnosis.Conclusion: Leukaemia or lymphoma with translocation t(8;14) or variant MYC translocation and precursor B-cell phenotype is a rare entity with a varied clinical presentation. This poses a challenge for diagnosis and classification and a clinical dilemma for the choice of treatment. | |
| Publisher | AOSIS | |
| Date | 2022-01-31 | |
| Identifier | 10.4102/ajlm.v11i1.1355 | |
| Source | African Journal of Laboratory Medicine; Vol 11, No 1 (2022); 5 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
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https://ajlmonline.org/index.php/ajlm/article/view/1355/2127
https://ajlmonline.org/index.php/ajlm/article/view/1355/2128
https://ajlmonline.org/index.php/ajlm/article/view/1355/2129
https://ajlmonline.org/index.php/ajlm/article/view/1355/2130
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