CT pulmonary angiography findings in HIV-infected patients referred for suspected pulmonary thrombo-embolic disease

SA Journal of Radiology

Field Value
Title CT pulmonary angiography findings in HIV-infected patients referred for suspected pulmonary thrombo-embolic disease
Creator Wiese, Diane Rajkumar, Leisha Lucas, Susan Clopton, David Benfield, Jacob DeBerry, Jason
Subject radiology; medical imaging CTPA; HIV; pulmonary embolism; imaging findings; radiological; prevalence
Description Background: South Africa bares a significant burden of HIV and imaging is commonly performed as part of the workup for respiratory distress.Objectives: The aim of this study was to document the prevalence of pulmonary thrombo-embolic disease (PTED) and other findings in HIV-infected patients referred for CT pulmonary angiography (CTPA) for suspected PTED.Method: Forty CTPA studies of documented HIV-infected individuals investigated for suspected PTED during a 1-year period were retrieved, anonymised and interpreted by three consultant radiologists. Inter-reader reliability was calculated using Free Marginal multi-rater Kappa.Results: Fourteen of the forty cases (35%) were positive for PTED. In the pulmonary embolism (PE)-positive group, 57.14% had peripheral disease and 42.86% had both peripheral and central disease. Associated findings in the PE-positive cases were pulmonary infarcts (17.5%), mosaic attenuation (17.5%) and linear atelectasis (7.5%). The most common incidental findings were solid pulmonary nodules (52.5%), non-wedge-shaped consolidation (45%), cardiomegaly (52.5%) and enlarged intra-thoracic lymph nodes (52.5%). Thirty per cent of the study population had findings related directly to the presence of PTED, whilst most cases in the study (77.5%) had pulmonary findings unrelated to PTED. In the PE-negative cases, 55% reported emergent findings that warranted immediate or urgent medical attention.Conclusion: Computed tomography pulmonary angiography imaging is critical for diagnosing PE. However, further investigation into the judicious application of CTPA in HIV-infected patients with suspected PTED is required, as CTPA findings in most of the cases in this study were unrelated to PE.
Publisher AOSIS
Contributor Not applicable
Date 2022-01-31
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cross-sectional; retrospective; descriptive
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajr.v26i1.2273
Source South African Journal of Radiology; Vol 26, No 1 (2022); 6 pages 2078-6778 1027-202X
Language eng
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https://sajr.org.za/index.php/sajr/article/view/2273/3107 https://sajr.org.za/index.php/sajr/article/view/2273/3108 https://sajr.org.za/index.php/sajr/article/view/2273/3109 https://sajr.org.za/index.php/sajr/article/view/2273/3110
Coverage Africa; South Africa; Gauteng; Johannesburg January 2018 - December 2018 Adults; Male and Female; HIV positive
Rights Copyright (c) 2022 Diane Wiese, Leisha Rajkumar, Susan Lucas, David Clopton, Jacob Benfield, Jason DeBerry https://creativecommons.org/licenses/by/4.0