The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | The influence of HIV infection and antiretroviral treatment on pulmonary function in individuals in an urban setting in sub-Saharan Africa | |
| Creator | van den Berg, Oda E. Shaddock, Erica J. Stacey, Sarah L. Feldman, Charles Barth, Roos E. Grobbee, Diederick E. Venter, Willem D.F. Klipstein-Grobusch, Kerstin Vos, Alinda G. | |
| Description | Background: With the roll-out of antiretroviral treatment (ART), the life expectancy of people with HIV and, hence, morbidity from non-communicable diseases, including pulmonary diseases, have increased.Objectives: This research study aims to investigate whether HIV infection and ART use are associated with pulmonary function, given the high frequency of pulmonary infections, including tuberculosis (TB), associated with HIV.Method: Adults living with HIV (ART-naïve, on first- or second-line ART), and age and sex matched HIV-negative controls were included in a cross-sectional study in Johannesburg, South Africa. Spirometry was performed to determine lung function, measuring the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC) and the FEV1/FVC ratio before (pre), and after (post), short-acting bronchodilator. The association of HIV infection and ART use with pulmonary function was analysed using linear regression models, adjusting for age, gender, body surface area (BSA), employment, education, smoking and TB.Results: Overall, 548 participants (62% women) were included with a mean age of 38 (standard deviation [s.d.] 9.5) years. No effect of HIV or ART on post-FEV1 was observed in adjusted analysis. Additional adjustment for TB resulted in a higher post-FEV1 in participants on ART compared with HIV-negative participants, whereas TB was associated with a lower FEV1. No effect of HIV and ART on post-FEV1/FVC was observed.Conclusion: HIV infection and ART use were not associated with reduced pulmonary function in this urban African population. Tuberculosis showed a mediating effect on the association between HIV, ART and pulmonary function. | |
| Publisher | AOSIS | |
| Date | 2021-11-15 | |
| Identifier | 10.4102/sajhivmed.v22i1.1312 | |
| Source | Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 8 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/1312/2642
https://sajhivmed.org.za/index.php/hivmed/article/view/1312/2643
https://sajhivmed.org.za/index.php/hivmed/article/view/1312/2644
https://sajhivmed.org.za/index.php/hivmed/article/view/1312/2645
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