Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia

Southern African Journal of HIV Medicine

Field Value
Title Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia
Creator Chikopela, Theresa Goma, Fastone Kaluba, Longa Mutale, Wilbroad Guure, Chris Heimburger, Douglas C. Koethe, John R.
Subject Clinical Science, Physiology Oxidative stress; endothelial activation, endothelial dysfunction; arterial stiffness, peroxynitrite
Description Background: Cardiovascular disease (CVD) prevalence is rising among persons with HIV (PLWH) in sub-Saharan Africa. Oxidative stress and endothelial activation, resulting in reduced vascular compliance, are contributors to CVD risk. However, there is a paucity of vascular health data in this population.Objectives: To assess the relationships of oxidative stress and endothelial activation with vascular stiffness among PLWH.Method: Fifty-four PLWH on antiretroviral therapy 5 years and 57 HIV-negative controls, all aged 18–45 years, were enrolled from the University Teaching Hospital, Lusaka, Zambia. Oxidative stress was measured by nitrotyrosine, a peroxynitrite biomarker, and endothelial activation by soluble intercellular adhesion molecule-1 (sICAM-1) plasma levels. Vascular compliance was measured using carotid-radial pulse wave velocity (crPWV) and arterial stiffness index (crASI).Results: PLWH had higher sICAM-1 levels (median 345 ng/mL) compared to controls (275 ng/mL, p 0.01), as well as higher nitrotyrosine levels (297 versus 182 nM; p = 0.02). Median crPWV was similar between the groups, but PLWH had higher crASI (2.4 versus 2.2 cm/ms; p 0.05). After adjusting for age, fat mass, and blood pressure, the estimated effect of a one unit increase in nitrotyrosine on crPWV were twofold higher in the PLWH, but neither reached significance. In a model pooling all participants, there were significant differences in the relationship of nitrotyrosine with crPWV and crASI by HIV status.Conclusion: PLWH in sub-Saharan Africa had significantly greater oxidative stress and endothelial activation compared to HIV-negative individuals. These factors may contribute to increased arterial stiffness and higher CVD prevalence in this population.
Publisher AOSIS
Contributor University of Zambia, Vanderbilt University
Date 2021-10-28
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v22i1.1298
Source Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 13 pages 2078-6751 1608-9693
Language eng
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Coverage sub Saharan-Africa, Zambia — Adults, blacks
Rights Copyright (c) 2021 Theresa Chikopela Chikopela, Fastone Goma, Longa Kaluba, Wilbroad Mutale, Chris Guure, Douglas C Heimburger, John R Koethe