Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia | |
| Creator | Chikopela, Theresa Goma, Fastone Kaluba, Longa Mutale, Wilbroad Guure, Chris Heimburger, Douglas C. Koethe, John R. | |
| Description | Background: Cardiovascular disease (CVD) prevalence is rising among persons with HIV (PLWH) in sub-Saharan Africa. Oxidative stress and endothelial activation, resulting in reduced vascular compliance, are contributors to CVD risk. However, there is a paucity of vascular health data in this population.Objectives: To assess the relationships of oxidative stress and endothelial activation with vascular stiffness among PLWH.Method: Fifty-four PLWH on antiretroviral therapy 5 years and 57 HIV-negative controls, all aged 18–45 years, were enrolled from the University Teaching Hospital, Lusaka, Zambia. Oxidative stress was measured by nitrotyrosine, a peroxynitrite biomarker, and endothelial activation by soluble intercellular adhesion molecule-1 (sICAM-1) plasma levels. Vascular compliance was measured using carotid-radial pulse wave velocity (crPWV) and arterial stiffness index (crASI).Results: PLWH had higher sICAM-1 levels (median 345 ng/mL) compared to controls (275 ng/mL, p 0.01), as well as higher nitrotyrosine levels (297 versus 182 nM; p = 0.02). Median crPWV was similar between the groups, but PLWH had higher crASI (2.4 versus 2.2 cm/ms; p 0.05). After adjusting for age, fat mass, and blood pressure, the estimated effect of a one unit increase in nitrotyrosine on crPWV were twofold higher in the PLWH, but neither reached significance. In a model pooling all participants, there were significant differences in the relationship of nitrotyrosine with crPWV and crASI by HIV status.Conclusion: PLWH in sub-Saharan Africa had significantly greater oxidative stress and endothelial activation compared to HIV-negative individuals. These factors may contribute to increased arterial stiffness and higher CVD prevalence in this population. | |
| Publisher | AOSIS | |
| Date | 2021-10-28 | |
| Identifier | 10.4102/sajhivmed.v22i1.1298 | |
| Source | Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 13 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/1298/2631
https://sajhivmed.org.za/index.php/hivmed/article/view/1298/2632
https://sajhivmed.org.za/index.php/hivmed/article/view/1298/2633
https://sajhivmed.org.za/index.php/hivmed/article/view/1298/2634
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