Optimised paediatric antiretroviral treatment to achieve the 95-95-95 goals

Southern African Journal of HIV Medicine

Field Value
Title Optimised paediatric antiretroviral treatment to achieve the 95-95-95 goals
Creator Archary, Moherndran van Zyl, Riana Sipambo, Nosisa Sorour, Gillian
Subject Paediatrics and Child Health; Paediatric Infectious Diseases paediatric; HIV/AIDS; ART; 95-95-95 goals; PMTCT
Description While the progress towards reaching the UNAIDS 95-95-95 targets in South African adults seems promising, the progress in the paediatric population is lagging far behind; only 79% percent of children living with HIV know their status. Of these, only 47% are on treatment, and a mere 34% of those are virally suppressed. Thus, virological suppression has been attained in only 13% of children living with HIV in South Africa. Multiple factors contribute to the high treatment failure rate, one of them being a lack of paediatric-friendly antiretroviral treatment (ART) formulations. For example, the Lopinavir/ritonavir syrup, which is the current mainstay of ART for young children, has an extremely unpleasant taste, contributing to the poor tolerability and lack of adherence by children using the formulation. Furthermore, the lack of appropriate formulations limits the optimisation of regimens, especially for young children and those who cannot swallow tablets. Switching from syrups to dispersible tablets will improve ease of administration and adherence and result in cost-saving. Despite the approval of simplified paediatric-friendly formulations internationally, including other sub-Saharan African countries, unnecessary delays are experienced in South Africa. Clinician groups and community organisations must speak up and demand that approvals be expedited to ensure the delivery of life-changing and life-saving formulations to our patients as a matter of urgency.
Publisher AOSIS
Contributor N/A
Date 2021-09-01
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — opinion
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v22i1.1278
Source Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 4 pages 2078-6751 1608-9693
Language eng
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info:eu-repo/grantAgreement/EC/FP7/000000 https://sajhivmed.org.za/index.php/hivmed/article/view/1278/2538 https://sajhivmed.org.za/index.php/hivmed/article/view/1278/2539 https://sajhivmed.org.za/index.php/hivmed/article/view/1278/2540 https://sajhivmed.org.za/index.php/hivmed/article/view/1278/2541
Coverage Durban; KwaZulu-Natal; South Africa birth to 14 years male; female; white; black; coloured; indian
Rights info:eu-repo/semantics/openAccess Copyright (c) 2021 Mohandran Archary https://creativecommons.org/licenses/by/4.0