Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)
SA Journal of Oncology
| Field | Value | |
| Title | Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016) | |
| Creator | Musaigwa, Fungai Grewal, Ravnit Abayomi, Akin Swanepoel, Carmen C. | |
| Description | Background: Chronic lymphocytic leukaemia (CLL) is a common lymphoproliferative disorder in developed countries. However, this condition is rare in Africa and there is a paucity of information on CLL, specifically on the continent.Aim: This study described, retrospectively, the frequency, demographics and laboratory features of CLL cases diagnosed from 2011 to 2016.Setting: Department of Pathology, National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town.Methods: A retrospective analysis was performed for all CLL diagnoses made between 01 January 2011 and 31 December 2016.Results: Eighty CLL cases were diagnosed between 2011 and 2016. Men and women presented with the disease equally (48.8% vs. 51.2%, p 0.05). The mean age at diagnosis was 66.79 years (range of 37–95 years) and the modal age range (36.3%) was 60–69 years. Men presented with the disease at a significantly younger age than women (mean = 64 years vs. mean = 69.5 years, p 0.05). There were three (3.75%) human immunodeficiency virus (HIV)-positive patients (age range 43–50 years). Chromosome 13q14 deletion was found in 6 out of 19 patients (31.6%). Trisomy 12 and deletion 11q22 were found in 5 out of 21 (24%) and 7 out of 21 (33.3%) patients, respectively. Deletions 13q34 and 17p were negative for 6 and 20 patients, respectively.Conclusion: Chronic lymphocytic leukaemia at our facility presented equally in men and women. Men presented with the disease at a younger age than women. Additionally, our findings suggested that HIV is uncommon amongst CLL patients tested for HIV. | |
| Publisher | AOSIS | |
| Date | 2021-06-29 | |
| Identifier | 10.4102/sajo.v5i0.168 | |
| Source | South African Journal of Oncology; Vol 5 (2021); 6 pages 2523-0646 2518-8704 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajo.org.za/index.php/sajo/article/view/168/488
https://sajo.org.za/index.php/sajo/article/view/168/489
https://sajo.org.za/index.php/sajo/article/view/168/490
https://sajo.org.za/index.php/sajo/article/view/168/491
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