Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid
Southern African Journal of HIV Medicine
Field | Value | |
Title | Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid | |
Creator | Decloedt, Eric H. Sinxadi, Phumla Z. Wiesner, Lubbe Joska, John A. Haas, David W. Maartens, Gary | |
Description | Background: Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacokinetics of their central nervous system (CNS) penetration.Objectives: We investigated genetic polymorphisms associated with CSF disposition of tenofovir and emtricitabine.Method: We collected paired plasma and CSF samples from 47 HIV-positive black South African adults who were virologically suppressed on efavirenz, tenofovir and emtricitabine. We considered 1846 single-nucleotide polymorphisms from seven relevant transporter genes (ABCC5, ABCG2, ABCB1, SLCO2B1, SCLO1A2, SLCO1B1 and ABCC4) and 782 met a linkage disequilibrium (LD)-pruning threshold.Results: The geometric mean (95% confidence interval [CI]) values for tenofovir and emtricitabine CSF-to-plasma concentration ratios were 0.023 (0.021–0.026) and 0.528 (0.460–0.605), respectively. In linear regression models, the lowest p-value for association with the tenofovir CSF-to-plasma ratio was ABCB1 rs1989830 (p = 1.2 × 10−3) and for emtricitabine, it was ABCC5 rs11921035 (p = 1.4 × 10−3). None withstood correction for multiple testing.Conclusion: No genetic polymorphisms were associated with plasma, CSF concentrations or CSF-to-plasma ratios for either tenofovir or emtricitabine. | |
Publisher | AOSIS | |
Date | 2021-04-28 | |
Identifier | 10.4102/sajhivmed.v22i1.1206 | |
Source | Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 24 pages 2078-6751 1608-9693 | |
Language | eng | |
Relation |
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https://sajhivmed.org.za/index.php/hivmed/article/view/1206/2411
https://sajhivmed.org.za/index.php/hivmed/article/view/1206/2410
https://sajhivmed.org.za/index.php/hivmed/article/view/1206/2412
https://sajhivmed.org.za/index.php/hivmed/article/view/1206/2409
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