Human immunodeficiency virus and mortality from coronavirus disease 2019: A systematic review and meta-analysis

Southern African Journal of HIV Medicine

Field Value
Title Human immunodeficiency virus and mortality from coronavirus disease 2019: A systematic review and meta-analysis
Creator Hariyanto, Timotius I. Rosalind, Jane Christian, Kevin Kurniawan, Andree
Subject Internal medicine; Infectious disease; Immunology coronavirus disease 2019; COVID-19; SARS-CoV-2; HIV; AIDS
Description Background: Persons living with human immunodeficiency virus (PLWH) constitute a vulnerable population in view of their impaired immune status. At this time, the full interaction between HIV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been incompletely described.Objective: The purpose of this study was to explore the impact of HIV and SARS-CoV-2 co-infection on mortality.Method: We systematically searched PubMed and the Europe PMC databases up to 19 January 2021, using specific keywords related to our aims. All published articles on coronavirus disease 2019 (COVID-19) and HIV were retrieved. The quality of the studies was evaluated using the Newcastle–Ottawa Scale for observational studies. Statistical analysis was performed with Review Manager version 5.4 and Comprehensive Meta-Analysis version 3 software.Results: A total of 28 studies including 18 255 040 COVID-19 patients were assessed in this meta-analysis. Overall, HIV was associated with a higher mortality from COVID-19 on random-effects modelling {odds ratio [OR] = 1.19 [95% confidence interval (CI) = 1.01–1.39], p = 0.03; I2 = 72%}. Meta-regression confirmed that this association was not influenced by age (p = 0.208), CD4 cell count (p = 0.353) or the presence of antiretroviral therapy (ART) (p = 0.647). Further subgroup analysis indicated that the association was only statistically significant in studies from Africa (OR = 1.13, p = 0.004) and the United States (OR = 1.30, p = 0.006).Conclusion: Whilst all persons ought to receive a SARS-CoV-2 vaccine, PLWH should be prioritised to minimise the risk of death because of COVID-19. The presence of HIV should be regarded as an important risk factor for future risk stratification of COVID-19.
Publisher AOSIS
Date 2021-04-15
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Systematic Review; Meta-Analysis
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v22i1.1220
Source Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 7 pages 2078-6751 1608-9693
Language eng
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Rights Copyright (c) 2021 Timotius I. Hariyanto, Jane Rosalind, Kevin Christian, Andree Kurniawan