Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy

Southern African Journal of HIV Medicine


 
 
Field Value
 
Title Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy
 
Creator Kaluba, Longa Goma, Fastone Guure, Chris Munsaka, Sody Mutale, Wilbroad Heimburger, Douglas C. Chikopela, Theresa Koethe, John R.
 
Subject Medicine endothelial dysfunction; immune activation; lean adults; antiretroviral therapy; arterial stiffness
Description Background: Greater T-cell activation was associated with reduced vascular compliance amongst persons living with HIV (PLWH) especially among overweight and obese individuals. There is a paucity of data regarding immune activation and arterial stiffness amongst PLWH in sub-Saharan Africa (SSA).Objective: To determine the association between immune activation and arterial stiffness in lean PLWH in SSA.Method: Forty-eight human immunodeficiency virus positive (HIV+) adults on antiretroviral therapy (ART) 5 years and 26 HIV-negative adults, all with BMI 25 kg/m2 and no history of CVD, were enrolled. The relationship of vascular compliance with circulating CD4+ and CD8+ naïve, memory, activated and senescent T cells, and serum 8-isoprostane was assessed by HIV status.Results: Increased immune activation was observed in the CD4+ and CD8+ T cells of PLWH, 16.7% vs. 8.9% and 22.0% vs. 12.4% respectively; p 0.001 (both). Furthermore, a higher proportion of senescent CD4+ T cells were associated with a lower carotid-femoral pulse wave velocity (cfPWV; p = 0.01), whilst a higher proportion of activated CD8+ T cells were associated with a lower carotid-radial pulse wave velocity (crPWV; p = 0.04), after adjustment for BMI and age. However, PLWH also had a higher median carotid-femoral augmentation index (cfAiX) (21.1% vs. 6.0%; p 0.05) in comparison to their HIV controls.Conclusion: Our population of lean PLWH had increased immune activation and higher cfAiX, a marker of arterial stiffness, compared to HIV-negative persons. The negative association between immune activation and arterial stiffness as measured by crPWV in PLHW on long-term treatment needs further elucidation.
 
Publisher AOSIS
 
Contributor
Date 2021-03-19
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cross sectional
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v22i1.1190
 
Source Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 9 pages 2078-6751 1608-9693
 
Language eng
 
Relation https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2349 https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2348 https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2350 https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2347
 
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Rights Copyright (c) 2021 Longa Kaluba, Fastone Goma, Chris Guure, Sody Munsaka, Wilbroad Mutale, Douglas C. Heimburger, Theresa Chikopela, John R. Koethe https://creativecommons.org/licenses/by/4.0