Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy | |
| Creator | Kaluba, Longa Goma, Fastone Guure, Chris Munsaka, Sody Mutale, Wilbroad Heimburger, Douglas C. Chikopela, Theresa Koethe, John R. | |
| Description | Background: Greater T-cell activation was associated with reduced vascular compliance amongst persons living with HIV (PLWH) especially among overweight and obese individuals. There is a paucity of data regarding immune activation and arterial stiffness amongst PLWH in sub-Saharan Africa (SSA).Objective: To determine the association between immune activation and arterial stiffness in lean PLWH in SSA.Method: Forty-eight human immunodeficiency virus positive (HIV+) adults on antiretroviral therapy (ART) 5 years and 26 HIV-negative adults, all with BMI 25 kg/m2 and no history of CVD, were enrolled. The relationship of vascular compliance with circulating CD4+ and CD8+ naïve, memory, activated and senescent T cells, and serum 8-isoprostane was assessed by HIV status.Results: Increased immune activation was observed in the CD4+ and CD8+ T cells of PLWH, 16.7% vs. 8.9% and 22.0% vs. 12.4% respectively; p 0.001 (both). Furthermore, a higher proportion of senescent CD4+ T cells were associated with a lower carotid-femoral pulse wave velocity (cfPWV; p = 0.01), whilst a higher proportion of activated CD8+ T cells were associated with a lower carotid-radial pulse wave velocity (crPWV; p = 0.04), after adjustment for BMI and age. However, PLWH also had a higher median carotid-femoral augmentation index (cfAiX) (21.1% vs. 6.0%; p 0.05) in comparison to their HIV controls.Conclusion: Our population of lean PLWH had increased immune activation and higher cfAiX, a marker of arterial stiffness, compared to HIV-negative persons. The negative association between immune activation and arterial stiffness as measured by crPWV in PLHW on long-term treatment needs further elucidation. | |
| Publisher | AOSIS | |
| Date | 2021-03-19 | |
| Identifier | 10.4102/sajhivmed.v22i1.1190 | |
| Source | Southern African Journal of HIV Medicine; Vol 22, No 1 (2021); 9 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2349
https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2348
https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2350
https://sajhivmed.org.za/index.php/hivmed/article/view/1190/2347
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