Unusual case of colorectal carcinoma with sarcoid-like mediastinal adenopathy and near-fatal DPD deficiency
SA Journal of Oncology
| Field | Value | |
| Title | Unusual case of colorectal carcinoma with sarcoid-like mediastinal adenopathy and near-fatal DPD deficiency | |
| Creator | Pillay, Shakti Terreblanche, Owen Devar, John Wadee, Ashraf | |
| Description | The liver is the commonest site for metastases in colorectal carcinoma; other isolated sites are considered extremely rare. 5-fluorouracil (5-FU) is the backbone of treatment for metastatic colorectal carcinoma (mCRC) and without it survival may be significantly reduced. It is primarily metabolised by dihydropyrimidine dehydrogenase (DPD). Testing for DPD deficiency is not a routine practice and toxicity will only manifest following drug challenge. There are limited standardised treatment guidelines in managing patients with severe drug reactions following 5-FU exposure. We describe a delayed presentation of life-threatening DPD deficiency in a patient with colorectal carcinoma and mediastinal lymphadenopathy. We describe our experience with chemotherapy in this difficult clinical scenario and highlight the importance of histological confirmation in unusual sites of metastatic disease. | |
| Publisher | AOSIS | |
| Date | 2021-03-12 | |
| Identifier | 10.4102/sajo.v5i0.160 | |
| Source | South African Journal of Oncology; Vol 5 (2021); 4 pages 2523-0646 2518-8704 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajo.org.za/index.php/sajo/article/view/160/459
https://sajo.org.za/index.php/sajo/article/view/160/458
https://sajo.org.za/index.php/sajo/article/view/160/460
https://sajo.org.za/index.php/sajo/article/view/160/457
|
|
ADVERTISEMENT
