Doramectin toxicity in a group of lions (Panthera leo)
Journal of the South African Veterinary Association
| Field | Value | |
| Title | Doramectin toxicity in a group of lions (Panthera leo) | |
| Creator | Lobetti, Remo G. Caldwell, Peter | |
| Description | Ten lions (Panthera leo) that were treated with a single injection of doramectin at a dose ranging between 0.2 mg/kg and 0.5 mg/kg showed clinical signs consistent with avermectin toxicity, namely ataxia, hallucinations, and mydriasis. Two subsequently died whereas the other eight lions recovered after 4–5 days with symptomatic therapy. Post-mortem examinations of the two that died showed cyanosis, severe pulmonary oedema, pleural effusion, and pericardial effusion, with histopathology not revealing any abnormalities. In both these lions, doramectin brain and liver tissue concentrations were elevated. Although doramectin is regularly used in wild felids, to date there have been no reports of avermectin toxicity in the literature. This article highlights the potential for doramectin toxicity in this species. | |
| Publisher | AOSIS | |
| Date | 2012-10-15 | |
| Identifier | 10.4102/jsava.v83i1.509 | |
| Source | Journal of the South African Veterinary Association; Vol 83, No 1 (2012); 3 pages 2224-9435 1019-9128 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jsava.co.za/index.php/jsava/article/view/509/956
https://jsava.co.za/index.php/jsava/article/view/509/987
https://jsava.co.za/index.php/jsava/article/view/509/957
https://jsava.co.za/index.php/jsava/article/view/509/955
|
|
ADVERTISEMENT
