Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation

Journal of Medicinal Plants for Economic Development

Field Value
Title Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation
Creator Yusuf, Amina J. Abdullahi, Musa I. Umar, Aisha M. Musa, Fatima
Subject — Vernonia glaberrima; lupeol; analgesic; anti-inflammatory; Lorke’s method.
Description Background: Steroids have been reported to possess analgesic and anti-inflammatory activities, and Vernonia glaberrima also possesses analgesic and anti-inflammatory properties.Aim: The aim of the study was to evaluate the effect of lupeol isolated from the n-hexane soluble fraction of the methanol leaf extract of V. glaberrima on pain and inflammation.Method: Lupeol was re-isolated from the leaf of V. glaberrima by using chromatographic procedures; it was subjected to analgesic and anti-inflammatory studies by using acetic acid-induced writhing test in mice and formalin-induced pain and inflammation in rats, respectively. The intraperitoneal lethal dose (LD50) of lupeol was determined by using Lorke’s method.Results: The results of the study showed that lupeol significantly (p 0.05) decreased writhing response at doses 12.5 mg/kg, 25.0 mg/kg and 50.0 mg/kg corresponding to percentage inhibition of 83.60%, 83.63% and 80.02%, respectively. This was higher than piroxicam, the standard drug (73.8%), at 10 mg/kg. The compound was also able to significantly (p 0.05) reduce nociceptive response in both phases of the formalin test, and there was a remarkable reduction of oedema by the compound at the second, third and fourth hours. The median LD50 of the compound was estimated to be greater than 5000 mg/kg.Conclusion: The findings of this study indicated that lupeol from the leaf of V. glaberrima has good analgesic and anti-inflammatory activity that validates the ethnomedicinal use of the plant in the treatment of pain and inflammatory conditions.
Publisher AOSIS Publishing
Contributor N/A
Date 2020-09-15
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Research article
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jomped.v4i1.84
Source Journal of Medicinal Plants for Economic Development; Vol 4, No 1 (2020); 5 pages 2616-4809 2519-559X
Language eng
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https://jomped.org/index.php/jomped/article/view/84/311 https://jomped.org/index.php/jomped/article/view/84/310 https://jomped.org/index.php/jomped/article/view/84/312 https://jomped.org/index.php/jomped/article/view/84/309
Coverage Africa; Nigeria; Sokoto — —
Rights Copyright (c) 2020 Amina J. Yusuf, Musa I. Abdullahi, Aisha M. Umar, Fatima Musa https://creativecommons.org/licenses/by/4.0