Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation
Journal of Medicinal Plants for Economic Development
| Field | Value | |
| Title | Effect of lupeol from Vernonia glaberrima (Asteraceae) on pain and inflammation | |
| Creator | Yusuf, Amina J. Abdullahi, Musa I. Umar, Aisha M. Musa, Fatima | |
| Description | Background: Steroids have been reported to possess analgesic and anti-inflammatory activities, and Vernonia glaberrima also possesses analgesic and anti-inflammatory properties.Aim: The aim of the study was to evaluate the effect of lupeol isolated from the n-hexane soluble fraction of the methanol leaf extract of V. glaberrima on pain and inflammation.Method: Lupeol was re-isolated from the leaf of V. glaberrima by using chromatographic procedures; it was subjected to analgesic and anti-inflammatory studies by using acetic acid-induced writhing test in mice and formalin-induced pain and inflammation in rats, respectively. The intraperitoneal lethal dose (LD50) of lupeol was determined by using Lorke’s method.Results: The results of the study showed that lupeol significantly (p 0.05) decreased writhing response at doses 12.5 mg/kg, 25.0 mg/kg and 50.0 mg/kg corresponding to percentage inhibition of 83.60%, 83.63% and 80.02%, respectively. This was higher than piroxicam, the standard drug (73.8%), at 10 mg/kg. The compound was also able to significantly (p 0.05) reduce nociceptive response in both phases of the formalin test, and there was a remarkable reduction of oedema by the compound at the second, third and fourth hours. The median LD50 of the compound was estimated to be greater than 5000 mg/kg.Conclusion: The findings of this study indicated that lupeol from the leaf of V. glaberrima has good analgesic and anti-inflammatory activity that validates the ethnomedicinal use of the plant in the treatment of pain and inflammatory conditions. | |
| Publisher | AOSIS Publishing | |
| Date | 2020-09-15 | |
| Identifier | 10.4102/jomped.v4i1.84 | |
| Source | Journal of Medicinal Plants for Economic Development; Vol 4, No 1 (2020); 5 pages 2616-4809 2519-559X | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jomped.org/index.php/jomped/article/view/84/311
https://jomped.org/index.php/jomped/article/view/84/310
https://jomped.org/index.php/jomped/article/view/84/312
https://jomped.org/index.php/jomped/article/view/84/309
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