Future approaches to clearing the latent human immunodeficiency virus reservoir: Beyond latency reversal

Southern African Journal of HIV Medicine

Field Value
Title Future approaches to clearing the latent human immunodeficiency virus reservoir: Beyond latency reversal
Creator Hayes, Alexander M.L.
Subject — HIV; latency reversal; viral reservoir; pro-apoptotic drugs; cART
Description Background: While combined antiretroviral therapy (cART) allows near-normal life expectancy for people living with human immunodeficiency virus (HIV), it is unable to cure the infection and so life long treatment is required.Objectives: The main barrier to curing HIV is the latent reservoir of cells, which is stable and resistant to cART.Method: Current approaches under investigation for clearing this reservoir propose a ‘Shock and Kill’ mechanism, in which active replication is induced in latent cells by latency reversal agents, theoretically allowing killing of the newly active cells.Results: However, previous studies have failed to achieve depletion of the T central memory cell reservoir, are unable to target other latent reservoirs and may be causing neurological damage to participants.Conclusion: Future approaches to clearing the latent reservoir may bypass latency reversal through the use of drugs that selectively induce apoptosis in infected cells. Several classes of these pro-apoptotic drugs have shown promise in in vitro and ex vivo studies, and may represent the basis of a future functional cure for HIV.
Publisher AOSIS
Date 2020-08-12
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajhivmed.v21i1.1089
Source Southern African Journal of HIV Medicine; Vol 21, No 1 (2020); 6 pages 2078-6751 1608-9693
Language eng
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https://sajhivmed.org.za/index.php/hivmed/article/view/1089/1955 https://sajhivmed.org.za/index.php/hivmed/article/view/1089/1954 https://sajhivmed.org.za/index.php/hivmed/article/view/1089/1956 https://sajhivmed.org.za/index.php/hivmed/article/view/1089/1953
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Rights Copyright (c) 2020 Alexander M.L. Hayes https://creativecommons.org/licenses/by/4.0